绿茶补充剂和奇特运动对核因素红色素2相关因子2活动的联合作用
Josh Thorley1, Craig Thomas1, Nicolas Thon1
1School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, LE11 3TU, UK.
European journal of applied physiology
|July 13, 2023
概括
奇特的运动和绿茶补充剂并没有增加核因素红色素2相关因子2 (NRF2) 的活性. 这项研究没有发现PBMCs中抗氧化反应元素 (ARE) 结合的协同效应.
科学领域:
- 运动生理学 运动生理学
- 营养生物化学 营养生物化学
- 分子生物学分子生物学
背景情况:
- 核因子红色素2相关因子2 (NRF2) 途径对于内源性抗氧化剂防御至关重要.
- 奇特的运动会诱导氧化应激,可能会激活NRF2.
- 绿茶中的多是已知的抗氧化剂,但它们与运动诱导的NRF2激活的相互作用尚不清楚.
研究的目的:
- 为了确定与绿茶补充剂的异常运动结合是否能协同增强NRF2活性.
- 研究这种组合对外周血液单核细胞 (PBMCs) 中抗氧化剂标记物的影响.
主要方法:
- 这是一项双盲随机研究,涉及24名男性.
- 参与者在6天的绿茶或安慰剂补充剂后进行了100次跳跃.
- 测量包括NRF2/抗氧化反应元素 (ARE) 结合,抗氧化酶活性 (CAT,GR),氧化应激标志物 (8-OHdG) 和白细胞计数.
主要成果:
- 奇特的运动没有显著增加NRF2/ARE结合,有或没有绿茶补充剂.
- 催化酶活性和8-OHdG的分泌保持不变.
- 氨酸还原酶活性随着运动而增加,但在不同组之间没有差异. 运动后白细胞和中性粒细胞数量增加.
结论:
- 奇特的运动单独或与绿茶补充剂相结合并不能显著上调PBMC中的NRF2活性.
- 该组合并没有对测量的抗氧化剂标记物产生协同效应.
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