空气污染和饮食:喘中的潜在相互作用暴露
Emily Brigham1,2, Alisa Hashimoto3, Neil E Alexis4,5
1Division of Respirology, University of British Columbia, Vancouver, BC, Canada. emily.brigham@ubc.ca.
Current allergy and asthma reports
|July 13, 2023
概括
饮食改变可以防止喘中空气污染的影响. 像纤维,抗氧化剂和omega-3脂肪酸这样的特定营养物质在减少呼吸道炎症和肺损伤方面表现有前途.
科学领域:
- 环境健康 环境健康
- 免疫学 免疫学 免疫学
- 营养科学 营养科学
背景情况:
- 喘管理受益于精确的表型和内型.
- 空气污染通过氧化应激和免疫反应引发呼吸道炎症.
- 中性粒细胞的招募和激活是关键的,但在污染物诱导的喘中没有得到充分的研究.
研究的目的:
- 审查有关饮食对喘呼吸系统对空气污染反应的影响的新兴文献.
- 探索饮食作为污染物引起的肺损伤的潜在干预措施.
主要方法:
- 对饮食成分和呼吸道炎症的体内和体外研究的审查.
- 对研究饮食对空气污染反应影响的小鼠模型的分析.
- 检查包括氧化应激和中性粒细胞功能在内的机制.
主要成果:
- 在动物模型中,饮食成分 (纤维,抗氧化剂,omega-3s) 显示出减轻呼吸道炎症的潜力.
- 饮食可以调节中性粒细胞的招募和功能,以应对空气污染.
- 新出现的证据表明,饮食影响呼吸系统对环境污染物的反应.
结论:
- 饮食修改是一个有希望的,但研究不足的,喘管理和保护空气污染的途径.
- 需要进一步的流行病学和因果研究来证实饮食的作用,重点关注中性粒细胞机制.
- 精确的生活方式干预,包括饮食,可能对污染环境中的呼吸系统健康至关重要.
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