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对Annona muricata的叶子产品质量的评价

Wai-Jo Jocelin Chan¹, Joanna E Harnett¹, Alexandra Meroni²

¹Faculty of Medicine and Health, School of Pharmacy, The University of Sydney, Sydney, Australia.

The Journal of pharmacy and pharmacology

|July 13, 2023

概括

商业上使用的草 (Annona muricata) 产品在质量和安全性上有很大的差异. 分析显示,生物活性化合物水平和微生物污染不一致,影响了癌症治疗疗效和患者安全.

科学领域:

植物化学植物化学
草药的质量控制草药的质量控制
药理学是指药理学,即药理学是指药理学.

背景情况:

安诺娜·穆里卡塔 (Annona muricata) 是一种植物,传统上用于癌症治疗.
人们对 graviola 的兴趣日益增加,需要对商业产品的质量和安全性进行评估.

研究的目的:

评估商用Annona muricata叶片产品的质量和安全性.
为了识别生物活性成分,污染物和微生物负载的变化.

主要方法:

分析了七种商业Annona muricata产品.
方法包括染色学 (TLC,HPLC,LC-MS),质谱学 (LRMS),NMR,微生物分析 (BP) 和重金属分析 (ICP-MS).
评估的质量指标:体重变化,阿诺素含量,乙原蛋白,污染物和微生物极限 (USP).

主要成果:

安诺的度 (1.05-3.09 mg/g) 和乙原蛋白的存在有显著的变化.
一个产品的标签含量不到标签中的50%.
一种产品超过了美国药典对总有氧微生物计数的限制.

结论:

商用Annona muricata叶片产品在质量和安全性方面表现出相当大的差异.
这些不一致对医疗保健提供者和依赖这些草药治疗的癌症患者有重大影响.

关键词:

安诺娜·穆里卡塔 (Annona muricata) 是一个美丽的城市.乙烯基基因的乙烯基基因.这就是安诺纳辛 (Annonacin).质量控制质量控制质量控制安全控制安全控制安全控制

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