可光交换的双 (胺):调节离子运输活动,独立于结合亲和力
David Villarón1, Jasper E Bos1, Fabien Kohl1
1Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands.
The Journal of organic chemistry
|July 13, 2023
概括
研究人员开发了可光切换的分子来控制跨膜的离子运输. 光可以触发离子运输,展示了一种光控制膜透性的新方法.
科学领域:
- 超分子化学 超分子化学
- 膜运输 运输 膜运输
- 摄影化学的使用.
背景情况:
- 跨越生物膜的阳离子运输对细胞功能至关重要.
- 开发用于控制的离子运输的合成系统是一个活跃的研究领域.
- 光控制的分子系统为动态过程提供精确的外部触发器.
研究的目的:
- 开发新的可光定位分子,用于控制跨双层膜的离子运输.
- 为了研究分子光异构化和离子运输效率之间的关系.
- 为了证明光感应*in situ*对膜透性的控制.
主要方法:
- 合成功能化的硬型基衍生物,其中包含基烯基单元.
- 使用UV-Vis光谱和核磁共振 (NMR) 光谱进行光物理特征.
- 使用H NMR定位的结合性亲和性研究.
- 使用基于光的方法进行阳离子运输测定.
主要成果:
- 合成的刚性stilbene衍生物表现出高光稳定性和 (E) 和 (Z) 异构体之间的高效光转换.
- (E) 和 (Z) 异构体与目标离子具有相似的结合亲和力.
- 基于光的输送试验显示,与 (E) 异构体相比, (Z) 异构体的阴离子输送活性显著更高.
- 阳离子运输可以有效地在现场使用光线触发.
结论:
- 调节离子运输不仅仅依赖于改变结合亲和力;光异构化起着关键作用.
- 开发的可光切换分子使光控制的阳离子通过双层膜传输.
- 这项工作为设计用于膜透性的先进光控制系统提供了基础.
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