药物诱导的急性胰腺炎:基于证据的分类 (修订)
Jasmine Saini1, Daniel Marino, Nison Badalov
1Maimonides Medical Center, State University of New York-Downstate Medical Center, Brooklyn, New York, USA.
Clinical and translational gastroenterology
|July 13, 2023
概括
由于证据薄弱,许多药物被错误地与急性胰腺炎联系在一起. 这一修订后的分类系统使用更高质量的研究来准确识别致病药物,改善药物诱导的急性胰腺炎的诊断.
科学领域:
- 胃肠病学 胃肠病学
- 临床药理学 临床药理学
背景情况:
- 药物诱导的急性胰腺炎的诊断是具有挑战性的.
- 以前的分类系统严重依赖案例报告,导致误解.
- 需要更高的证据价值研究来准确识别药物诱导的急性胰腺炎.
研究的目的:
- 建议对药物诱导的急性胰腺炎进行修订,基于证据的分类系统.
- 为了提高识别致病药物的准确性.
- 使用推,开发和评估 (GRADE) 评级标准.
主要方法:
- 在文献中搜索药物诱导的急性胰腺炎病例报告.
- 根据证据质量,将涉及的药物分为四组.
- 在证据评估中应用GRADE标准.
主要成果:
- 在文献中确定了141种药物可能导致急性胰腺炎.
- 106种药物得到了高质量的病例报告的支持.
- 只有3种药物从随机对照试验中得到证据,包括6 - 默卡普托普林和阿扎西奥普林.
结论:
- 大多数与急性胰腺炎相关的药物具有低质量的证据.
- 使用更高层次证据的修订分类系统至关重要.
- 准确识别致病药物将改善患者的诊断和管理.
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