氧酸盐/聚氨支架用于骨组织工程
Tianyu Zhang1, Jingxuan Li1, Yahui Wang1
1Department of Biomedical Engineering, Research Center for Nanobiomaterials and Regenerative Medicine, College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan, PR China.
Tissue engineering. Part B, Reviews
|July 13, 2023
概括
由于其生物相容性和生物降解性,酸/聚氨 (HA/PU) 支架对骨组织工程具有前景. 本综述涵盖了它们的设计,合成和用于骨修复和药物输送的应用.
科学领域:
- 生物材料科学 生物材料科学
- 再生医学是一种再生医学.
- 整形外科工程 整形外科工程
背景情况:
- 聚氨 (PU) 和陶支架是关键的合成骨材料.
- 将PU与酸 (如酸 (HA)) 结合起来,可以提高机械性能和生物相容性.
研究的目的:
- 审查用于骨组织工程的酸/聚氨 (HA/PU) 支架的最新进展.
- 讨论这些支架的设计,合成,改造和生物特性.
主要方法:
- 对HA/PU支架研究的文献综述.
- 对脚手架属性的分析,包括骨质生成和生物相容性.
- 检查骨修复和药物输送中的应用.
主要成果:
- 多种HA/PU支架表现出有希望的骨质生成,抗微生物和生物相容性特征.
- 这些支架在骨修复,缺陷填充和药物输送应用中是有效的.
结论:
- HA/PU支架代表了合成骨材料的重大发展.
- 它们的定制性质支持从骨再生到长期植入物等各种应用.
相关概念视频
Bone Structure
Within the skeletal system, the structure of a bone, or osseous tissue, can be exemplified in a long bone, like the femur, where there are two types of osseous tissue: cortical and cancellous.
Bone as Supporting Connective Tissue
Bone tissue forms the internal skeleton of vertebrate animals, providing structure to the body.
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts— that give the...
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts— that give the...
The Bone Matrix
Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in acid or...
Essential Minerals for Bone Health
The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Corrosion of Reinforcement
The corrosion of steel reinforcement within concrete is a process influenced by the material's inherent properties and external factors. The high pH level of around 13, provided by calcium hydroxide present in concrete, initially protects the steel reinforcement by promoting the formation of a passive iron oxide layer on its surface.
However, over time and under certain conditions like carbonation, chloride ingress, and cracking this protective state can be compromised. Steel has areas with...
However, over time and under certain conditions like carbonation, chloride ingress, and cracking this protective state can be compromised. Steel has areas with...


