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相关概念视频

Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

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The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
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Immune Surveillance by NK Cells and Phagocytes01:25

Immune Surveillance by NK Cells and Phagocytes

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Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
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Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

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The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
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Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

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Overview
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Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

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The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
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相关实验视频

Updated: Jul 23, 2025

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus KSHV
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Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus KSHV

Published on: September 14, 2010

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巨细胞驱动KSHV B细胞延迟时间.

Agnieszka Szymula1, Gabriela Samayoa-Reyes2, Sidney Ogolla3

  • 1Departments of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA; Program in Virology, Harvard Medical School, Boston, MA 02115, USA.

Cell reports
|July 13, 2023
PubMed
概括

卡波西卡波西 (Kaposi Kaposi) 是一个

关键词:
B细胞是B细胞的组成部分.CP: 免疫学 免疫学在 KSHVV 找 KSHV卡波西的肉瘤相关的疹病毒.潜在的感染 潜在的感染巨细胞是一个巨细胞.疟疾 疟疾 是一种疾病.一个单细胞单细胞.血细胞的血细胞是什么

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相关实验视频

Last Updated: Jul 23, 2025

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus KSHV
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科学领域:

  • 病毒学 病毒学
  • 免疫学 免疫学 免疫学
  • 细胞生物学 细胞生物学

背景情况:

  • 卡波西肉瘤疹病毒 (KSHV) 建立了终身B细胞感染,但体外感染是无效的.
  • KSHV流行病学类似于疟疾等寄生虫感染,这些感染与单细胞数量升高有关.
  • 单细胞/巨细胞在KSHV病原和潜伏中的作用仍然不清楚.

研究的目的:

  • 调查单细胞和巨细胞在卡波西肉瘤疹病毒 (KSHV) 感染和潜伏中的作用.
  • 探索KSHV流行病学和由单细胞性特征的寄生虫感染之间的联系.

主要方法:

  • 单细胞和M-CSF分化的巨细胞在体外感染KSHV.
  • 蛋白质组分析以确定巨细胞分泌的因素.
  • 在共同培养系统中评估B细胞存活,增殖和分化.
  • 在KSHV流行地区的疟疾儿童中分析单细胞水平.

主要成果:

  • KSHV有效地感染单细胞和M2巨细胞.
  • 受感染的巨细胞产生促进B细胞存活,增殖和等离子体细胞分化的因素.
  • 巨细胞驱动KSHV感染的血细胞分化和长期的病毒潜伏.
  • 在肯尼亚疟疾儿童中观察到单细胞水平升高,与KSHV流行病相关.

结论:

  • 单核细胞,包括单核细胞和巨细胞,在促进KSHV B细胞感染和潜伏方面发挥着关键作用.
  • 巨衍生因素对于支持KSHV感染的B细胞至关重要.
  • 单核细胞的丰富性可能解释了KSHV感染的地理分布.