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更新了实施疾病预防控制中心关于检测C型肝炎病毒感染的建议的操作指南
MMWR. Morbidity and mortality weekly report
|July 13, 2023
概括
完整的型肝炎病毒 (HCV) 测试需要在抗体测试反应时进行HCVRNA测试. 单次检查样本采集确保了完整的HCV检测,并将更多患者与治愈治疗联系起来.
科学领域:
- 肝病学和病毒免疫学
- 公共卫生和传染病管理
背景情况:
- 目前的C型肝炎病毒 (HCV) 诊断指南建议采用两步抗体-然后-RNA测试序列.
- 不完整的HCV检测,定义为反应性抗体测试没有随后的RNA测试,历史上影响了大约三分之一的患者.
- 不完整的检测阻碍了国家消除HCV感染的努力.
研究的目的:
- 澄清和更新关于HCV检测程序的指导,以确保完整的诊断测试.
- 推广促进在反应性抗体结果后立即进行HCV RNA测试的策略.
- 改善患者与HCV感染的护理和治愈性抗病毒疗法的联系.
主要方法:
- 建议所有HCV查站点实施一次性检查样本采集协议.
- 倡导对所有HCV抗体反应样本进行自动HCVRNA测试.
- 阻止需要多次患者访问以收集样本的测试策略.
主要成果:
- 单次检查样本采集可以自动测试对抗体反应的个体的HCV RNA.
- 预计这种方法将大大减少不完整的HCV检测.
- 增加全面检测预计将改善及时诊断和治疗的患者比例.
结论:
- 实施一次性采样采集和自动RNA测试对于实现国家HCV消除目标至关重要.
- 这一更新的测试策略确保了全面的HCV诊断.
- 简化测试途径将提高患者获得治愈性抗病毒疗法的机会.
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