旧世界中世纪的Treponema pallidum复杂的Treponematosis:一个病例报告
Hamadou Oumarou Hama1,2, Mahmoud A Boualam1,2, Anthony Levasseur1,2
1Aix-Marseille University, IRD, MEPHI, Institut Méditerranée Infection, Marseille, France.
The Journal of infectious diseases
|July 13, 2023
概括
古代欧洲的骨样本揭示了Treponema pallidum复杂的病原体在普遍接受的1493年引入之前的800年存在于欧洲,挑战了既定的医学历史.
科学领域:
- 古生物生物学 古生物生物学
- 传染病史 传染病史 传染病史
- 医学微生物学 医学微生物学
背景情况:
- 主流理论认为,Treponema pallidum复杂病原体于1493年引入欧洲.
- 这个介绍与克里斯托弗·哥伦布从中美洲返回的军队有关.
研究的目的:
- 为了调查在7-8世纪法国大腿骨中发现的一种传染性骨损伤.
- 为了确定1493年哥伦布探险队之前的病原体的存在和性质.
主要方法:
- 古老的自身免疫组织化学用于病原体识别.
- 直接的基因组学用于遗传分析.
- 古代血清学用于抗体检测.
- 对7世纪至8世纪的股骨 (RS-1003) 和对照股骨 (R-1003) 的分析.
主要成果:
- 在RS-1003股骨病变中微观检测Treponema pallidum复杂病原体.
- 遗传学分析确定了一种祖先的T. pallidum复杂病原体.
- 在RS-1003中,古色素学证实了积极的T. pallidum特异性抗原发现.
结论:
- 在1493年之前,欧洲人对Treponema pallidum复杂病原体并不天真.
- 一种祖先的病原体在中美洲菌株之前几个世纪在欧洲流传.
- 这些发现挑战了风病学和医学微生物学的既定教条.
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