Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Neuroretinal damage associated with pituitary macroadenoma: endocrine and radiological predictors and correlation with optical coherence tomography-derived biomarkers.

Frontiers in endocrinology·2026
Same author

3D OCT-Based Retinal Biomarker Analysis for Automatic Regional-Wise Characterization of Neurodegenerative Diseases.

Journal of imaging informatics in medicine·2026
Same author

Clues to prognosis in anterior ischemic optic neuropathy: an optical coherence tomography angiography study.

International journal of ophthalmology·2026
Same author

Visual Quality in Acute Retinal Pigment Epitheliitis: A Case Report.

Reports (MDPI)·2026
Same author

Advances in pharmacogenomics.

Medicina clinica·2026
Same author

Three-Year Outcomes and Safety of the XEN63 Gel Stent: A Multicenter Prospective Study in Primary Open-Angle Glaucoma.

Journal of clinical medicine·2026

相关实验视频

Updated: Jun 18, 2026

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool
11:35

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool

Published on: June 30, 2014

58.1K

通过使用新的OCT工具评估多发性硬化症的严重程度.

Elisa Viladés1,2, Beatriz Cordón1,2, Javier Pérez-Velilla1

  • 1Miguel Servet Ophthalmology Research and Innovation Group (GIMSO), Aragon Institute for Health Research (IIS Aragón), University of Zaragoza, Zaragoza, Spain.

PloS one
|July 13, 2023
PubMed
概括

一个新的后极协议有效地检测视网膜神经纤维层 (RNFL) 和状细胞层 (GCL) 在多发性硬化症 (MS) 患者的差异,即使在早期阶段. RNFL厚度与残疾相关,而GCL厚度与疾病持续时间相关.

更多相关视频

Measuring Progressive Neurological Disability in a Mouse Model of Multiple Sclerosis
08:11

Measuring Progressive Neurological Disability in a Mouse Model of Multiple Sclerosis

Published on: November 14, 2016

11.1K
Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
02:28

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients

Published on: March 1, 2024

432

相关实验视频

Last Updated: Jun 18, 2026

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool
11:35

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool

Published on: June 30, 2014

58.1K
Measuring Progressive Neurological Disability in a Mouse Model of Multiple Sclerosis
08:11

Measuring Progressive Neurological Disability in a Mouse Model of Multiple Sclerosis

Published on: November 14, 2016

11.1K
Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
02:28

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients

Published on: March 1, 2024

432

科学领域:

  • 眼科医生 眼科 眼科
  • 神经科学是一个神经科学.
  • 医疗成像医学成像

背景情况:

  • 多发性硬化症 (MS) 是一种慢性神经疾病,影响中枢神经系统.
  • 视网膜神经纤维层 (RNFL) 和质细胞层 (GCL) 稀薄是MS中神经退行症的潜在生物标志物.
  • 早期发现和监测MS进展对于患者管理至关重要.

研究的目的:

  • 与健康对照人群相比,评估一种新型的后极协议,用于检测MS患者的RNFL和GCL厚度变化.
  • 在MS患者中调查RNFL和GCL厚度与疾病持续时间和扩展残疾状态量表 (EDSS) 之间的相关性.

主要方法:

  • 分析了缓解复发性多发性硬化症 (RR-MS) 患者的100只眼睛和健康对照组的66只眼睛.
  • 根据从第一次临床症状出现 (CSO) 到临床确定的MS (CDMS) 转换的时间进行子组分析.
  • 使用光学连贯断层扫描 (OCT) 来测量RNFL和GCL厚度.

主要成果:

  • 在RR-MS患者和对照人群之间观察到RNFL和GCL厚度的显著差异.
  • 通过CSO和CDMS分类的子组之间也注意到厚度差异.
  • 在RNFL/GCL厚度和CSO/CDMS之间发现了中等到强烈的相关性,在RNFL厚度和EDSS之间存在强烈的相关性.

结论:

  • 后极协议是评估多发性硬化症的一个有价值的工具,即使在早期疾病阶段也能识别出差异.
  • RNFL厚度与MS相关的残疾 (EDSS) 有很强的相关性.
  • GCL厚度与MS持续时间的相关性更好.