系统性免疫炎症指数作为动脉支架后预后的预测指标,与C反应性蛋白相比
Shuji Morikawa1,2, Kenji Okumura3, Naoya Inoue1,2
1Department of Cardiology, Chutoen General Medical Center, Kakegawa, Shizuoka, Japan.
PloS one
|July 13, 2023
概括
系统性免疫炎症指数 (SII) 预测了动脉支架 (CAS) 患者的长期结果. 与C反应蛋白 (CRP) 相比,SII是预后的优越炎症标志物.
科学领域:
- 心血管医学 心血管医学
- 炎症研究 炎症研究
- 医学诊断 医学诊断 医学诊断
背景情况:
- 免疫-炎症过程是动脉样硬化进展的组成部分.
- 系统性免疫炎症指数 (SII) 在预测中风和缺血性心脏病患者的结果方面显示出潜力.
- C-反应蛋白 (CRP) 是一个已知的炎症标记物.
研究的目的:
- 评估SII对接受动脉支架 (CAS) 患者的短期和长期预后的预测能力.
- 在CAS患者中比较SII与CRP的预测性能.
主要方法:
- 一个单一中心的回顾性研究,涉及129名接受CAS的患者.
- 根据SII水平,患者被分为三级.
- 主要终点是主要不良心脏和脑血管事件 (MACCE);次要终点包括中风发病率和全因死亡.
主要成果:
- 较高的SII三位数与长期MACCE和中风率的增加相关.
- 最高的SII三位数 (>647) 独立预测了长期中风 (HR 21.3) 和MACCE (HR 3.98).
- 与CRP (AUC 0.64) 相比,SII对长期MACCE表现出更高的预测能力 (AUC 0.72).
结论:
- 在CAS后的患者中,SII是长期预后的独立预测因素.
- 建议SII在这个患者队列中比CRP更有效的炎症预后标志物.
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