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在儿童急性淋巴细胞白血病幸存者的运动期间基质氧化

Émilie Bertrand^1,2, Maxime Caru^2,3, Sophia Morel^2,4

¹Laboratory of Pathophysiology of EXercise (LPEX), School of Kinesiology and Physical Activity Sciences, Faculty of Medicine, University of Montreal, Montreal, Quebec, Canada.

Pediatric hematology and oncology

|July 13, 2023

概括

儿童急性淋巴细胞白血病 (ALL) 幸存者在运动期间表现出减少的最大脂肪氧化. 这表明癌症治疗对代谢健康的长期影响,独立于多克索鲁比剂量.

科学领域:

儿科瘤学儿科瘤学
运动生理学运动生理学
心脏代谢健康状况

背景情况:

儿童急性淋巴细胞白血病 (ALL) 幸存者面临长期心脏代谢并发症的风险增加.
运动期间最大脂肪氧化 (MFO) 是心脏代谢健康的关键指标,与代谢风险因素有关.
了解ALL幸存者的运动期间基质利用率对于评估长期健康影响至关重要.

研究的目的:

在童年运动期间描述碳水化合物和脂肪氧化模式,所有幸存者.
为了比较不同预后风险组的基质氧化率,包括用德克斯拉素治疗的人.

主要方法:

间接热量计被用于测量基质氧化率在心肺运动测试在250个童年ALL幸存者.
最大脂肪氧化 (MFO),峰值脂肪氧化 (Fatmax) 和交叉点是使用最适合多项式曲线来确定的.
统计分析将这些参数与标准风险 (SR),高风险用德克斯拉 (HR+DEX) 和高风险 (HR) 组进行了比较.

主要成果:

童年所有幸存者在运动期间表现出低脂肪氧化,并在低强度运动时利用碳水化合物.
预后风险组之间MFO,Fatmax和交叉点没有显著差异 (p > 0.05).
与HR+DEX和HR组的男性相比,SR组的男性表现出更高的MFO (p = 0.04).

结论:

童年所有幸存者在运动期间表现出脂肪氧化受损,无论累积的多克索鲁比剂量如何.
这些发现凸显了癌症治疗对幸存者的潜在长期代谢后果.
临床医生应该意识到基质氧化变化是ALL幸存者的长期健康风险的潜在指标.

关键词:

急性淋巴细胞白血病 (Acute Lymphoblastic Leukemia) 是一种急性淋巴细胞白血病.进行心肺运动测试.最大的脂肪氧化.儿童癌症的生存率儿童癌症的生存率基质氧化过程中的基质氧化.

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