印度儿童多焦点/扩散性婴儿肝血栓瘤中的普罗普兰诺洛单疗法:一个案例系列
Gautam Ray1, Kausik Das2, Avik Sarkar3
1Division of Pediatric Gastroenterology, School of Digestive and Liver Disease (SDLD), Institute of Post Graduate Medical Education & Research (IPGMER), 244, AJC Bose Road, Kolkata, PIN-700020, West Bengal, India.
Journal of clinical and experimental hepatology
|July 13, 2023
概括
普罗普拉诺洛单一疗法有效治疗印度儿童的婴儿肝血管瘤 (IHH),显示了88.9%的应答率. 这项研究支持propranolol作为亚洲人群中复杂IHH的安全和有效治疗方法.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 肝病学 肝病学是一种肝病学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 婴儿肝脏血管瘤 (IHH) 是最常见的儿科肝脏瘤.
- 多焦点和扩散性IHH可能危及生命,需要及时治疗.
- 普罗普拉诺洛尔是IHH的确立的第一线治疗方法,在高加索人群中拥有广泛的数据.
研究的目的:
- 评价印度儿童多焦点和扩散IHH.propranolol单疗法的疗效和安全性.
- 为亚洲儿科患者群体提供有关普拉诺洛尔治疗结果的数据.
- 评估印度一群患有复杂IHH的儿童的反应率和不良事件.
主要方法:
- 一个回顾性,单中心研究,对9名印度儿童进行了多焦点或扩散的IHH.
- 患者接受了中位数为3.2毫克/千克/天的普拉诺洛尔单一疗法,平均持续时间为12个月.
- 分析了临床数据,包括出现症状和治疗反应.
主要成果:
- 在9名患者中,有8名 (88.9%) 显示对普罗普兰诺洛单一治疗有良好的反应.
- 常见的表现包括甲状腺功能低下,心力衰竭和大血管转移.
- 一名患者出现了复发,但对重新治疗有反应;安全性概况是有利的.
结论:
- 普罗普拉诺洛尔单一疗法在印度儿童中表现出高疗效和有利的安全性概况,这些儿童患有复杂的IHH.
- 这项研究扩大了propranolol在亚洲儿科患者中使用的证据基础.
- 这些发现支持propranolol作为南亚严重IHH的关键治疗选择.
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