甲状腺功能低下症和非酒精性脂肪肝疾病之间的相互关系,一个横截面研究
Sarah Elshinshawy1, Hemmat Elhaddad1, Shereen Abdel Alem2
1Department of Internal Medicine, Faculty of Medicine, Cairo University, Cairo, 11562, Egypt.
Journal of clinical and experimental hepatology
|July 13, 2023
概括
甲状腺功能低下症,包括明显和亚临床形式,与非酒精性脂肪肝疾病 (NAFLD) 的更高可能性有关. 甲状腺激素水平和胰岛素抵抗是这些患者肝硬化症的关键预测因素.
科学领域:
- 内分泌学 在内分泌学.
- 肝病学 肝病学是一种肝病学.
- 代谢疾病 代谢疾病
背景情况:
- 甲状腺激素是新陈代谢的重要调节者.
- 它们在非酒精性脂肪性肝病 (NAFLD) 发病过程中的作用受到争议.
- 这项研究调查了甲状腺功能低下症和NAFLD之间的关联.
研究的目的:
- 为了确定明显或亚临床的甲状腺功能低下是否与NAFLD有关.
- 在甲状腺功能低下个体中确定肝硬化症的预测因子.
主要方法:
- 一项横截面研究,将60名甲状腺功能低下患者与30名健康对照人进行比较.
- 通过控制衰减参数 (CAP) 评估了人体测量数据,实验室标记物,纤维细胞生长因子21 (FGF21) 和肝肥胖症.
主要成果:
- 甲状腺功能低下的参与者显示肝酶,脂质样本,HbA1c,胰岛素耐药性 (HOMA-IR) 和较低的自由甲状腺素 (FT4) 显著改变.
- 在甲状腺功能低下组中,较高的CAP值表明肝硬化症增加 (P < 0.001).
- FT4,BMI和HOMA-IR是肥胖症的独立预测因素;FGF21不是一个显著的标志物.
结论:
- 亚临床和明显的甲状腺功能低下症与NAFLD的患病率增加有关.
- 甲状腺功能低下患者的FGF21水平升高需要进一步调查其在肝硬化症中的作用.
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