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预测通过网络相互作用的转化调节与亚洲诱导的突触可塑性

Nurhadi Ibrahim¹, Ibrahim Nadian¹, Dimas R Noor^2,3

¹Department of Medical Physiology and Biophysics, Faculty of Medicine, Universitas Indonesia, Jakarta 10430, Indonesia.

TheScientificWorldJournal

|July 13, 2023

概括

亚洲菌通过向参与突触可塑性的关键蛋白质,显示出对阿尔茨海默病 (AD) 治疗的潜力. 这种天然化合物可能通过与AKT和mTOR信号通路相互作用,为AD治疗提供新的途径.

科学领域:

神经科学是一个神经科学.
药理学药理学是指药理学的学科.
计算生物学计算生物学

背景情况:

全球预期寿命的增加与年龄相关疾病的增加有关,包括阿尔茨海默氏症 (AD).
随着阿尔茨海默氏症的日益流行,它给社会经济带来了巨大的负担.
由于缺乏确定的治疗方法,天然产品正在被探索为AD的补充或替代治疗剂.

研究的目的:

为了研究亚洲在阿尔茨海默病中的潜在治疗效果.
为了确定与突触可塑性相关的*Centella asiatica*成分的分子标.

主要方法:

利用蛋白质数据库来识别与突触可塑性相关的基因.
使用Cytoscape进行了蛋白质与蛋白质相互作用 (PPI) 分析.
采用STITCH,Gene Ontology (GO) 和KEGG的途径分析来预测*Centella asiatica*目标及其途径.

主要成果:

确定了446个与突触可塑性相关的蛋白质编码基因.
蛋白与蛋白相互作用和KEGG通路分析表明AKT和mTORC1通路的潜在抑制.
关键的向蛋白包括TSC1,Rheb和FMRP.

结论:

*亚洲细胞*通过与TSC1,Rheb和FMRP等蛋白质的相互作用,显示出在阿尔茨海默病治疗中的潜力.
该化合物有效地与AKT1和mTOR信号通路结合.
亚洲可能对阿尔茨海默氏病具有显著的治疗功效.

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