在太空辐射之后的 postsynaptic 密度辐射签名
Soren Impey1,2, Carl Pelz1, Lara-Kirstie Riparip3
1Department of Pediatrics, Oregon Stem Cell Center, Oregon Health and Science University, Portland, OR, United States.
Frontiers in physiology
|July 13, 2023
概括
太空辐射,特别是28Si离子辐射,低剂量对小鼠的认知功能有损. 这种认知衰退与海马体内DNA甲基化和基因表达的变化有关.
科学领域:
- 神经科学是一个神经科学.
- 空间生物学 空间生物学
- 辐射生物学 辐射生物学
背景情况:
- 太空辐射对宇航员健康构成风险,特别是在脑功能方面.
- 了解大脑对太空辐射的反应对于长期太空任务至关重要.
研究的目的:
- 研究28Si离子辐射对小鼠认知表现的影响.
- 为了确定这些影响是否与海马DNA甲基化和基因表达的改变有关.
主要方法:
- 给小鼠照射了28Si离子 (600 MeV/n),剂量不同 (0.3,0.6,0.9 Gy).
- 认知功能在辐射后两周使用对象识别测试进行评估.
- 分析了海马体DNA甲基化 (5hmC) 和基因表达特征.
主要成果:
- 在0.3Gy的28Si离子辐射下观察到认知障碍,但在更高剂量时没有.
- 认知障碍与改变的基因表达和海马体中的5hmC概况相关.
- 在不同类型的离子中 (质子,56Fe,28Si) 发现了涉及45个基因的共同空间辐射突触签名.
结论:
- 低剂量的28Si离子辐射可以通过改变海马体DNA甲基化和基因表达来损害认知功能.
- 暴露于太空辐射会在大脑中诱导突触信号,影响谷氨酸干细胞通路.
- 大脑对太空辐射的反应涉及突触重塑,特别是在刺激突触.
更多相关视频
相关概念视频
Synaptic Signaling
70.0K
Neurons communicate at synapses, or junctions, to excite or inhibit the activity of other neurons or target cells, such as muscles. Synapses may be chemical or electrical.
70.0K
Fusion of Secretory Vesicles with the Plasma Membrane
15.9K
Proteins and neurotransmitters in secretory vesicles can be released from a cell upon vesicle docking, priming, and fusion with the plasma membrane. Vesicles are docked and primed in preparation for the quick exocytosis of their contents in response to a stimulus. The fusion process is mainly carried out by a SNAP Receptor or SNARE complex, consisting of synaptobrevin, syntaxin-1, and SNAP-25.
In 1993, Jim Rothman proposed that the antiparallel pairing of vesicular and transmembrane SNAREs, or...
In 1993, Jim Rothman proposed that the antiparallel pairing of vesicular and transmembrane SNAREs, or...
15.9K
Synaptic Signaling
5.7K
Neurons communicate at synapses, or junctions, to excite or inhibit the activity of other neurons or target cells, such as muscles. Synapses may be chemical or electrical.
Most synapses are chemical, meaning an electrical impulse or action potential spurs the release of chemical messengers called neurotransmitters. The neuron sending the signal is called the presynaptic neuron, and the neuron receiving the signal is the postsynaptic neuron.
The presynaptic neuron fires an action potential that...
Most synapses are chemical, meaning an electrical impulse or action potential spurs the release of chemical messengers called neurotransmitters. The neuron sending the signal is called the presynaptic neuron, and the neuron receiving the signal is the postsynaptic neuron.
The presynaptic neuron fires an action potential that...
5.7K
Chemical Synapses
9.5K
Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
9.5K
Chemical Synapses
10.9K
Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
10.9K
Postsynaptic Potential (PSP)
11.7K
Postsynaptic potential (PSP) refers to a change in the electrical potential of a neuron when neurotransmitters released by presynaptic neurons bind to postsynaptic receptors. This potential can either be excitatory, leading to depolarization and ultimately action potential generation, or inhibitory, leading to hyperpolarization and suppression of the postsynaptic neuron.
There are two types of receptors: ionotropic and metabotropic.
The ionotropic receptor is the membrane protein that has an...
There are two types of receptors: ionotropic and metabotropic.
The ionotropic receptor is the membrane protein that has an...
11.7K


