循环里林促进炎症,并在急性和长期COVID-19病例中调节疾病活动
Laurent Calvier1,2, Aleksandra Drelich3, Jason Hsu3
1Department of Molecular Genetics, University of Texas (UT) Southwestern Medical Center, Dallas, TX, United States.
Frontiers in immunology
|July 13, 2023
概括
在严重的COVID-19期间,里林蛋白水平增加,导致炎症和疾病严重程度. 抑制Reelin在小鼠模型中降低了死亡率,这表明它.
科学领域:
- 免疫学 免疫学 免疫学
- 血管生物学 血管生物学
- 传染性疾病 传染性疾病
背景情况:
- 严重的COVID-19与血栓栓塞问题和过度炎症有关,可能导致长期COVID.
- 以前的研究表明,循环中的Reelin在非COVID环境中促进白细胞透和血栓形成.
- 这项研究调查了Reelin在COVID-19相关的内皮功能障碍和超级炎症中的作用.
研究的目的:
- 为了确定Reelin是否在COVID-19患者中升高,并且与疾病活性相关.
- 为了研究Reelin水平和严重COVID-19的炎症标志物之间的关系.
- 在SARS-CoV-2小鼠模型中评估Reelin抑制的治疗潜力.
主要方法:
- 量化了COVID-19患者的里林水平,并将其与疾病严重程度和炎症标志物 (细胞因子,化学因子,粘附分子) 相关联.
- 在长期COVID队列中评估了Reelin和炎症标志物水平.
- 向感染SARS-CoV-2的HACE2转基因小鼠预防性地使用抗Reelin抗体CR-50.
主要成果:
- 在COVID-19患者中,里林水平升高,与疾病活性和特定的炎症标志物 (IL-1α,IL-4,IP-10,MIP-1β,ICAM-1) 相相关.
- 在严重的COVID-19中观察到一种超炎症状态,其特征是细胞因子,化学因子和粘附标记的增加.
- 长期COVID患者的里林和炎症标志物正常化,表明过度炎症的解决.
- 在小鼠中,CR-50治疗减少了SARS-CoV-2感染后的死亡率和疾病严重程度.
结论:
- 里林在COVID-19病变发生过程中扮演着直接的炎症作用.
- 里林是严重的SARS-CoV-2感染的潜在治疗点.
- 这些发现对治疗COVID-19和其他自身炎症性疾病有意义.
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