相关实验视频
Updated: Jul 23, 2025

A Murine Model of Group B Streptococcus Vaginal Colonization
Published on: November 16, 2016
在日本对母婴接种B组链球菌疫苗的成本效益分析
Sumire Sorano1,2, Simon R Procter3, Anna C Seale3,4
1Department of Disease Control, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, United Kingdom.
在日本的一种母体B型链球菌 (GBS) 疫苗可以预防婴儿GBS疾病,死亡和死产. 这种疫苗可能具有成本效益,比目前的查方法更有显著的健康益处.
科学领域:
- 围产期健康 围产期健康
- 预防传染病 预防传染病
- 卫生经济学 卫生经济学
背景情况:
- 乙组链球菌 (GBS) 是新生儿感染,早产和死产的主要原因.
- 目前日本对GBS的指导方针包括产前查和产后抗菌预防 (IAP),这并不能防止所有与GBS相关的不良结果.
- 目前正在开发的孕产妇GBS疫苗旨在预防婴儿GBS疾病,并可能提供更广泛的围产期益处.
研究的目的:
- 评估日本未来产妇GBS疫苗的成本效益.
- 为了比较一种母体GBS疫苗接种加上查/IAP与单独查/IAP的策略.
- 评估GBS疫苗的经济影响,该疫苗还可以预防早产.
主要方法:
- 使用决策树模型来估计GBS疾病病例,死亡率,神经发育障碍,死胎,成本和质量调整后生命年 (QALYs).
- 该研究计算了成本效益的疫苗门价格为500万日元/QALY.
- 场景分析探讨了疫苗预防早产的影响.
主要成果:
- 每年在日本,母婴GBS接种疫苗可以预防额外的142例婴儿GBS病例,5例死亡,21例NDI病例和13例死产.
- 增量成本效益比 (ICER) 为378万日元/QALY,疫苗价格为5000日元/剂量.
- 包括死产所损失的QALY,使ICER降至178万日元/QALY;预防早产的疫苗使ICER降至188万日元/QALY.
结论:
- 在日本,孕产妇GBS疫苗的成本效益很可能是5,000日元/剂量,显著改善围产期的结果.
- 疫苗对额外的不良周产期结果的有效性,如早产,增强了健康益处和成本效益.
- 这些发现支持母婴GBS接种疫苗在减少疾病负担和改善婴儿和母亲健康方面的潜在价值.
更多相关视频
06:22Standardization of Transfer across Labs between Flow Cytometers for Detection of Lymphocytes in Japanese Encephalitis Vaccinated Children
Published on: February 10, 2023
06:26Author Spotlight: Optimizing CFU Determination for Efficient Assessment of TB Vaccine Efficacy and Antigen Presentation Analysis
Published on: July 28, 2023
相关概念视频
Vaccinations
Healthcare Associated Infections II: Preventive Measures
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
Antimicrobial Effectiveness
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Factors Affecting the Risk of Infection
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
Statistical Methods for Analyzing Epidemiological Data