心脏成像监测策略是否会影响早期乳腺癌患者的结果?
Kai Yi Wu1, Sarah Parent2, Lingyu Xu3
1Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, AB, Canada.
Frontiers in oncology
|July 13, 2023
概括
在早期乳腺癌患者中,选择心声回声扫描或多门采集 (MUGA) 扫描对结果没有影响. 常规的随访心脏成像没有与改善生存率或减少心力衰竭事件有关.
科学领域:
- 心脏病学 心脏病学
- 在瘤学瘤学.
- 医疗成像医学成像
背景情况:
- 乳腺癌疗法可能导致心脏毒性.
- 心声图和MUGA扫描是常见的监测高风险患者的心脏功能.
- 最佳的成像策略及其对结果的影响仍然不清楚.
研究的目的:
- 为了比较心声回声扫描与MUGA扫描在乳腺癌治疗期间评估心脏功能的有效性.
- 为了确定治疗前成像模式对患者结果的影响.
- 评估常规随访心脏成像的必要性.
主要方法:
- 确定了一组早期 (0-3) 乳腺癌患者的队列,这些患者接受了治疗前的心声图或MUGA扫描 (2010-2019).
- 收集了人口统计,病史,成像和临床事件的数据.
- 主要结局是所有死因或心力衰竭事件的复合,使用单变量和多变量方法进行分析.
主要成果:
- 1028名患者接受了MUGA扫描,1032人接受了心声回声扫描,具有可比的基线特征.
- 两组之间在死亡或心力衰竭的综合结果中没有显著差异.
- 没有随访成像的患者与随访成像的患者相比,对复合结果的调整风险相似.
结论:
- 治疗前心声学或MUGA扫描选择没有影响早期乳腺癌患者死亡或心力衰竭的风险.
- 很大一部分患者没有进行后续成像,没有出现不良结果.
- 由于事件发生率低,长期心脏成像监测的价值需要进一步调查.
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