在一般人群中血清丸激素与功能之间的关系中的性别差异
Anna C van der Burgh1,2, Elif Aribas2, M Arfan Ikram2
1Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands.
Kidney international reports
|July 13, 2023
概括
测试激素 测试激素是什么
科学领域:
- 内分泌学和脏学.
背景情况:
- 关于丸激素在功能下降中的作用的证据有限,特别是在女性中.
- 需要基于人口的研究来澄清这些关联.
研究的目的:
- 为了研究血清丸激素水平和功能在男性和女性的大型基于人口的队列之间的关联.
- 探索这种关系中潜在的性别差异.
主要方法:
- 包括4095名男性和5389名女性 (≥45岁) 测量了血清丸激素,SHBG,肌素和囊素C.
- 评估功能,使用估计的膜过率 (eGFRcreat,eGFRcys) 和尿中的白蛋白与肌素比率 (ACR).
- 采用线性回归和线性混合模型,按性别分层.
主要成果:
- 在男性中,较高的自由与较低的eGFRcreat和ACR相关,以及更高的eGFRcys.
- 在男性中,较高的总丸激素与更好的eGFR创造有关.
- 在女性中,随着时间的推移,较高的自由与较低的eGFRcreat和eGFRcys有关.
结论:
- 在丸激素与功能相关性方面观察到性别差异:男性呈阳性,女性呈阴性.
- 基于血清囊素C的eGFR对于这些关联可能是一个比基于肌素的eGFR更敏感的标志物.
- 需要进一步的研究来证实这些发现,并探索潜在的机制.
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