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产内长时间暴露氧气对胎儿代谢状态的影响:随机对照试验的二次分析
Fang Chuai1, Tong Dong1, Yuan Liu1
1Department of Obstetrics and Gynaecology, Sixth Medical Center, Chinese PLA General Hospital, Beijing, China.
Frontiers in endocrinology
|July 13, 2023
概括
在分娩期间母亲的氧气暴露没有影响胎儿乳酸或心率跟踪. 然而,它确实改变了带动脉代谢特征,表明胎儿的潜在生化变化.
科学领域:
- 产科和妇科 产科和妇科
- 胎儿医学 胎儿医学
- 新生儿研究新生儿研究
背景情况:
- 在分娩期间给母亲氧气是常见的,但它对胎儿健康的影响尚未完全理解.
- 之前的研究已经产生了相互矛盾的结果,关于氧气治疗对胎儿的酸状态和心率的影响.
研究的目的:
- 为了评估产妇在分娩期间长时间接触氧气对胎儿酸状态的影响.
- 评估对胎儿心率跟踪的影响.
- 分析带动脉代谢物的变化.
主要方法:
- 一项对中国北京三所高等教学医院进行的研究的二次分析.
- 大约140名分娩潜伏阶段的妇女被随机分配到接受10升/分钟的氧气或室内空气,直到分娩.
- 带动脉乳酸和91种其他代谢物是主要的结局措施.
主要成果:
- 在氧气和室内空气组之间,带动脉乳酸水平没有显著差异.
- 长时间暴露于氧气并没有影响高风险II类胎儿心率跟踪的发生率或持续时间.
- 在91个带动脉代谢物中发现了显著的变化,独立于氧化应激.
结论:
- 母亲在分娩期间长时间接触氧气不会对胎儿带动脉乳酸或高风险胎儿心率跟踪产生不利影响.
- 氧气的使用可能会导致胎儿带动脉代谢特征的改变.
- 需要进一步的研究来了解这些代谢变化的临床意义.
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