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相关概念视频

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

8.7K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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siRNA - Small Interfering RNAs02:30

siRNA - Small Interfering RNAs

16.8K
Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
16.8K
Translational Regulation01:29

Translational Regulation

45
Translational regulation in prokaryotes ensures efficient protein synthesis by controlling ribosome access to mRNA. This regulation is mediated by secondary RNA structures, including translational riboswitches, RNA thermometers, and small RNAs (sRNAs), which respond to intracellular and environmental signals to modulate gene expression.Translational RiboswitchesRiboswitches in the leader region of mRNAs can regulate translation by altering the accessibility of the Shine-Dalgarno (SD) sequence,...
45
Types of RNA01:20

Types of RNA

5.9K
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
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Alternative RNA Splicing02:18

Alternative RNA Splicing

21.4K
Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
21.4K
MicroRNAs01:22

MicroRNAs

21.4K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
21.4K

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相关实验视频

Updated: Jul 23, 2025

Desthiobiotin-Streptavidin-Affinity Mediated Purification of RNA-Interacting Proteins in Mesothelioma Cells
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Desthiobiotin-Streptavidin-Affinity Mediated Purification of RNA-Interacting Proteins in Mesothelioma Cells

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在不同的疾病中,SIRT1和非编码RNA之间的相互作用.

Soudeh Ghafouri-Fard1, Hamed Shoorei2,3, Bashdar Mahmud Hussen4

  • 1Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Frontiers in genetics
|July 13, 2023
PubMed
概括

赛尔图因1 (SIRT1) 与非编码RNA如lncRNA,miRNA和circRNA相互作用. 这些相互作用在疾病中至关重要,并为各种疾病提供潜在的治疗点.

关键词:
一个SIRT1系统.生物标志物生物标志物环RNA 环RNA 是一个环RNA.在 lncRNA 中,这是一个小RNARNA.

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Deacetylation Assays to Unravel the Interplay between Sirtuins SIRT2 and Specific Protein-substrates
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相关实验视频

Last Updated: Jul 23, 2025

Desthiobiotin-Streptavidin-Affinity Mediated Purification of RNA-Interacting Proteins in Mesothelioma Cells
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Deacetylation Assays to Unravel the Interplay between Sirtuins SIRT2 and Specific Protein-substrates
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科学领域:

  • 分子生物学分子生物学
  • 遗传学 遗传学 是一个
  • 生物化学 生物化学

背景情况:

  • 赛尔图因1 (SIRT1) 是一种脱乙酶,在细胞过程中起着关键作用.
  • SIRT1与代谢疾病,衰老,炎症和癌症的发病有关.
  • 非编码RNAs,包括lncRNAs,miRNAs和circRNAs,越来越多地被认为是它们在生物过程中的调节作用.

研究的目的:

  • 审查SIRT1与三大类非编码RNA之间的相互作用.
  • 突出这些相互作用在各种病理条件中的参与.
  • 根据SIRT1非编码RNA轴来识别潜在的治疗点.

主要方法:

  • 对研究SIRT1和非编码RNA相互作用的文献综述.
  • 在特定疾病的背景下分析已识别的相互作用.
  • 已知涉及SIRT1.1的circRNA/miRNA和lncRNA/miRNA对的总结.

主要成果:

  • 已确定多个lncRNA,miRNA和circRNA与SIRT1.1相互作用.
  • 这些相互作用在广泛的疾病中被观察到,包括心血管疾病,代谢障碍和癌症.
  • 已经记录了不同非编码RNA和SIRT1之间的协同相互作用.

结论:

  • 非编码RNA在调节SIRT1活动和功能的过程中起着重要作用.
  • SIRT1非编码RNA调节轴代表了新型治疗策略的有希望的目标.
  • 对这些相互作用的进一步研究可能会导致治疗各种人类疾病的进步.