素-框架封装微针贴片促进头发生长
Yating Yang1, Pei Wang1, Yan Gong1
1Department of Plastic and Reconstructive Surgery, Shanghai Key Laboratory of Tissue Engineering, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.
Theranostics
|July 13, 2023
概括
一种新的黄框架微针贴片通过通过皮肤传递活性化合物来有效地促进头发的再生. 这种创新的治疗方法增强了皮肤细胞的活力,减少了细胞亡,并在动物模型中对抗脱发.
科学领域:
- 生物材料科学 生物材料科学
- 皮肤病学 皮肤病学
- 纳米技术 纳米技术
背景情况:
- 脱发是一种常见的美学问题,具有显著的心理社会影响.
- 目前的治疗方法通常针对单一的途径,且药物透率有限.
- 开发先进的药物输送系统对于有效的脱发疗法至关重要.
研究的目的:
- 开发和评估一种素-框架 (ZnMOF) 封装的玛-多聚胺酸微针贴片 (ZnMOF-MN) 用于通过皮肤促进头发生长.
- 为了研究ZnMOF的抗氧化,抗解和抗雄激素作用.
- 在体内评估ZnMOF-MN在促进头发再生和伤口愈合方面的疗效.
主要方法:
- 使用FE-SEM,DLS,XRD制造和表征ZnMOF纳米粒子和ZnMOF-MN贴片.
- 在体外评估ZnMOF释放,细胞毒性和对皮肤乳头细胞 (DPC) 对氧化应激和二二 (DHT) 的影响.
- 在体内评估ZnMOF-MN在雄激素脱发 (AGA) 和伤口愈合小鼠模型中的疗效,分析毛囊,血管新生 (CD31+) 和细胞增殖 (Ki67+).
主要成果:
- 已成功合成ZnMOF纳米粒子并将其纳入微针贴片中,以持续释放Zn2+和黄素.
- 在实验室中,ZnMOF对DPCs表现出显著的保护作用,增强活力,抑制亡,并逆转DHT诱导的抑制.
- 在AGA模型中,ZnMOF-MN治疗加速了伤口愈合,增加了毛囊密度,促进了血管生成和细胞增殖,并显著改善了头发的再生.
结论:
- 该ZnMOF-MN贴片作为一个有效的,患者友好的皮肤透过系统用于头发生长.
- 这种多功能方法解决了发和伤口愈合所涉及的多种机制.
- MOF-MN对各种脱发状况显示出有前途的治疗潜力.
相关概念视频
01:20Accessory Structures of the Skin: Hair Growth and Types
1.5K
Hair growth begins with the production of keratinocytes by the basal cells of the hair bulb. As new cells are deposited at the hair bulb, the hair shaft is pushed through the follicle toward the surface. Keratinization is completed as the cells are pushed to the skin surface to form the shaft of hair that is externally visible. The external hair is completely dead and composed entirely of keratin. Hair can be cut or shaven without damaging the hair structure because the cut is superficial. Most...
1.5K
01:06Multipotency and Niche of Bulge Stem Cell
3.7K
A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
3.7K
01:16Accessory Structures of the Skin: Hair and Hair Follicles
2.4K
Hair and hair follicles are integral components of the integumentary system. Hair is a filamentous structure composed mainly of a protein called keratin. It is found on the surface of the skin throughout the body, except for areas such as the palms of the hands and soles of the feet.
Hair is a keratinous filament growing out of the epidermis. It is primarily made of dead, keratinized cells. Hair strands originate at the epidermal penetration called the hair follicle. The hair shaft is the part...
Hair is a keratinous filament growing out of the epidermis. It is primarily made of dead, keratinized cells. Hair strands originate at the epidermal penetration called the hair follicle. The hair shaft is the part...
2.4K