极高密度脂蛋白胆固醇与心血管不良结果之间的关联:系统性审查和元分析
Guanwei Zhang1, Jiajuan Guo2, Hongguang Jin2
1College of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, China.
Frontiers in cardiovascular medicine
|July 13, 2023
概括
极高的高密度脂蛋白胆固醇 (HDL-C) 水平与全因死亡,心血管疾病 (CVD) 死亡和中风的风险增加有关. 需要进一步的研究来证实这些关联.
科学领域:
- 心血管科学 心血管科学
- 流行病学 流行病学
- 生物化学 生物化学
背景情况:
- 高密度脂蛋白胆固醇 (HDL-C) 与心血管不良结果之间的关系需要进一步研究.
- 现有的研究还没有充分探讨极高的HDL-C水平的影响.
研究的目的:
- 调查极高的HDL-C与全因死亡率之间的关联.
- 检查极高的HDL-C与动脉样硬化心血管疾病 (CVD) 死亡率之间的联系.
- 评估患有极高HDL-C的人中风的风险.
主要方法:
- 在Embase,PubMed,Cochrane图书馆和科学网上进行了系统的文献搜索.
- 这项分析包括了17个队列研究,其中有19,630,829名参与者.
- 使用随机效应模型将相对风险 (RRs) 和95%置信区间 (CI) 结合起来.
主要成果:
- 极高的HDL-C与所有原因死亡率增加15%有关 (RR=1.15,95% CI:1.05-1.25).
- 观察到心血管疾病死亡率增加了14% (RR=1.14,95% CI:0.96-1.35) 和中风风险增加了14% (RR=1.14,95% CI:0.82-1.58).
- 亚组分析表明,女性心血管疾病死亡风险降低,男性中风风险降低,HDL-C极高.
结论:
- 极高的HDL-C水平与全因死亡率,心血管疾病死亡率和中风的风险增加有关.
- 这些发现表明HDL-C水平和心血管结果之间存在复杂的关系.
- 需要进一步的精心设计的研究来验证这些结果并阐明潜在的机制.
相关概念视频
Blood Studies for Cardiovascular System III: Serum Lipid Profile
201
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
201
Coronary Artery Disease IV: Preventive Measures
25
Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
25
Coronary Artery Disease I: Introduction
25
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
25
Lipids: Dietary Sources and Requirements
851
Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ...
851
Cholesterol: Significance and Regulation
592
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
592
Coronary Artery Disease II: Pathophysiology
13
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
13


