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Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
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Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
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Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
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Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
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Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease
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针对CADASIL严重程度的新型分级系统:一个多中心的横截面研究.

Bhrugun Anisetti1, Elena Greco1, Eldina Stojadinovic1

  • 1Department of Neurology, Mayo Clinic, Jacksonville, FL, USA.

Cerebral circulation - cognition and behavior
|July 13, 2023
PubMed
概括

对于带有皮下心脏病发作和白细胞大脑病变 (CADASIL) 的大脑自体主导性动脉病变的新分级系统是可靠和实用的临床使用. 这个系统有效地根据疾病严重程度对患者进行分类,并通过将更高的等级与增加的血管风险因素相关联,帮助研究.

关键词:
卡达西尔 (CADASIL) 是一种评级系统的分级系统.多中心的多中心.

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科学领域:

  • 神经学 神经学
  • 遗传学 是一个遗传学.
  • 血管医学 血管医学

背景情况:

  • 大脑自体主导性动脉病变与皮下心脏病发作和白细胞脑病变 (CADASIL) 是一种渐进的,遗传性脑微血管病变.
  • 卡达西尔在临床表现 (表型) 中表现出显著的变异性.

研究的目的:

  • 评估CADASIL在美国多个中心的新分级系统的通用性和可靠性.
  • 在现实临床环境中评估拟议的CADASIL分级系统.

主要方法:

  • 在5个专门中心对138名已确认CADASIL的成年患者的电子病历 (EMR) 进行回顾性审查.
  • 根据临床严重程度,患者被分为5个等级 (0-4). 评估了评价者之间的可靠性 (IRR).
  • 人口统计,血管风险因素和神经成像数据被收集和分析.

主要成果:

  • 在CADASIL分级系统证明了可接受的评级者之间的可靠性 (κ=0.855).
  • 成绩的分布是这样的:0级 (10.9%),1级 (36.2%),2级 (44.2%),3级 (8.7%),以及4级 (0%).
  • 较高的严重程度与评估时的年龄较小,高血压和糖尿病的患病率增加以及血管风险因素的较大负担有关.

结论:

  • 拟议的CADASIL分级系统是用于表型CADASIL患者的务实和可靠工具.
  • 该系统只需要标准的临床数据,使其在常规实践中很容易适用.
  • 这种分级系统可以促进对CADASIL的观察和干预研究中的患者分类.