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Updated: Jul 23, 2025

Author Spotlight: Streamlining Protein Target Prediction and Validation via Molecular Docking and CETSA
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Author Spotlight: Streamlining Protein Target Prediction and Validation via Molecular Docking and CETSA

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药用化学 洞察小分子凯尔奇式ECH相关蛋白的发展 1-核因子 红色素 2-相关因子 2 (Keap1-Nrf2) 蛋白质-蛋白质相互作用抑制剂

Ziquan Zhao1,2, Ruitian Dong1,2, Qidong You1,2

  • 1State Key Laboratory of Natural Medicines and Jiang Su Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China.

Journal of medicinal chemistry
|July 13, 2023
PubMed
概括

针对Keap1-Nrf2与小分子的相互作用,提供了一种促进细胞抵抗氧化应激防御的新方法. 这种方法正在迅速推进各种疾病的药物发现.

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相关概念视频

Protein-protein Interfaces02:04

Protein-protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
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