单一剂Cefotetan的使用用于Gustilo-Anderson III型开放骨折预防
Garrhett G Via1, David A Brueggeman1, Victoria A Murray1
1Wright State University Department of Orthopaedic Surgery, 30 E. Apple St., Ste 2200, Dayton, Ohio 45409 United States of America.
Injury
|July 13, 2023
概括
与传统疗法相比,对Gustilo-Anderson Type III开口骨折的单一治疗显示出抗生素管理的前景,感染率相似,但抗生素剂量较少,返回手术室的时间较少.
科学领域:
- 整形外科手术 整形外科手术
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 对于Gustilo-Anderson Type III开口骨折的传统预防性抗生素包括塞法林,一种氨基糖化物和青素.
- 塞福特坦是第二代塞法洛斯波林,具有广泛的活性,但在骨科预防中尚未确立.
- 这项研究调查了cefotetan作为这些骨折的单一治疗剂.
研究的目的:
- 评估单独治疗塞福泰坦疗法的疗效和结果,与治疗III型开口骨折的传统抗生素疗法相比.
- 为了比较手术部位感染 (SSI) 率,深部感染率,非联合和其他临床结果.
- 评估抗生素管理,包括剂量,成本和门诊抗生素使用情况.
主要方法:
- 对138例古斯蒂洛-安德森III型开放骨折的回顾性队列研究 (2010年9月 - 2019年12月).
- 比较单一治疗 (n=42) 和非单一治疗 (n=42) 的Cefotetan队列.
- 分析包括并发病,骨折特征,医院内指标和1年的术后结果.
主要成果:
- 在cefotetan队列中,室内抗生素剂量较少,门诊抗生素使用较少.
- 塞福泰坦使用与重返手术室的回归率显著降低 (35.7%与54.2%相比).
- 感染率 (SSI和深层感染) 在céfotetan和非céfotetan组之间是相似的.
结论:
- 单独治疗塞福泰坦可能为III型开口骨折提供优越的抗生素管理.
- 它显示了与传统的多药预防方案相似的传染性后果.
- 需要进一步调查塞福泰坦在骨科创伤预防中的作用.
更多相关视频
10:31Surgical Angiogenesis in Porcine Tibial Allotransplantation: A New Large Animal Bone Vascularized Composite Allotransplantation Model
Published on: August 13, 2017
7.7K
07:50Author Spotlight: Scalable Drug Screening Protocol for Efficient Discovery of M. abscessus Treatments
Published on: October 25, 2024
1.7K
相关概念视频
01:18Endocarditis III: Medical Management
8
Infective endocarditis management involves a multifaceted approach encompassing infection prevention, lifestyle modifications, pharmacological therapy, and surgical management.Infection Prevention:Hand Hygiene: Thorough handwashing is crucial to prevent the spread of infection. Hand hygiene should be performed regularly, especially before and after using the restroom.Oral Hygiene: Good oral hygiene is essential. It includes brushing teeth immediately after waking up and before bed, flossing...
8
01:29Endocarditis IV: Nursing Management
16
Infective endocarditis (IE) is a chronic infection of the heart's endocardium, primarily affecting the heart valves. A detailed nursing assessment for a patient with IE involves collecting subjective and objective data to ensure an accurate diagnosis and timely intervention.Subjective DataThe nurse gathers information about the patient's symptoms and complaints during the subjective assessment. Patients with infective endocarditis often report non-specific symptoms that can mimic other...
16
01:23Hand hygiene
3.4K
Asepsis is the practice of preventing or breaking the chain of infection. The nurse employs aseptic techniques to prevent the spread of microorganisms and reduce the risk of diseases. Hand hygiene is the cornerstone of aseptic techniques and is classified into medical and surgical asepsis. Medical asepsis includes hand hygiene and the use of gloves. Surgical asepsis, or the sterile technique, refers to practices that render and keep objects and areas free of microorganisms.
Hand washing...
Hand washing...
3.4K
01:26Tonsillitis II: Management
139
This lesson will focus on the different treatment options for managing tonsillitis, which typically depend on the cause and severity.
139
01:28Pneumonia IV: Management
360
The treatment of pneumonia varies based on its severity and the causative pathogen. Here is a structured approach to managing pneumonia, integrating pharmaceutical and supportive care strategies.
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
360
01:26Pulmonary Tuberculosis IV
165
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
165