Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Overview of Transposition and Recombination02:13

Overview of Transposition and Recombination

15.8K
Transposons make up a significant part of genomes of various organisms. Therefore, it is believed that transposition played a major evolutionary role in speciation by changing genome sizes and modifying gene expression patterns. For example, in bacteria, transposition can lead to conferring antibiotic resistance. Movement of transposable elements within the genetic pool of pathogenic bacteria can aid in transfer of antibiotic-resistant genetic elements. In eukaryotes, transposons can carry out...
15.8K
DNA-only Transposons02:57

DNA-only Transposons

14.6K
DNA-only transposons are called autonomous transposons since they code for the enzyme transposase that is required for the transposition mechanism. Insertion of transposons can alter gene functions in multiple ways. They can mutate the gene, alter gene expression by introducing a novel promoter or insulator sequence, introduce new splice sites, and change the mRNA transcripts produced, or remodel chromatin structure.
The donor site from where the transposon is excised is either degraded or...
14.6K
Gastrulation01:56

Gastrulation

57.6K
Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata...
57.6K
Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

11.6K
As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
11.6K
LTR Retrotransposons03:08

LTR Retrotransposons

17.6K
LTR retrotransposons are class I transposable elements with long terminal repeats flanking an internal coding region. These elements are less abundant in mammals compared to other class I transposable elements. About 8 percent of human genomic DNA comprises LTR retrotransposons. Some of the common examples of LTR retrotransposons are Ty elements in yeast and Copia elements in Drosophila.
The internal coding region of LTR retrotransposons and their mechanism of transposition closely resembles a...
17.6K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Human primordial germ cell heterogeneity in vitro is associated with distinctive biological states.

Cellular & molecular biology letters·2026
Same author

Considerations for the future of in vitro gametogenesis in fertility care.

Nature biotechnology·2026
Same author

Sex-specific expression and function of TRIM28 during mouse primordial germ differentiation.

iScience·2025
Same author

Defining the cell and molecular origins of the primate ovarian reserve.

Nature communications·2025
Same author

TFAP2A+ embryonic progenitor cells undergo fate diversification to give rise to human amnion, germline, and mesoderm.

bioRxiv : the preprint server for biology·2025
Same author

Testicular somatic and germ cell maturation during rhesus macaque development.

Proceedings of the National Academy of Sciences of the United States of America·2025

相关实验视频

Updated: Jul 23, 2025

Loss- and Gain-of-function Approach to Investigate Early Cell Fate Determinants in Preimplantation Mouse Embryos
08:43

Loss- and Gain-of-function Approach to Investigate Early Cell Fate Determinants in Preimplantation Mouse Embryos

Published on: June 6, 2016

8.9K

在早期人类胚胎发育和胚胎模型中的可转移元素

Jonathan A DiRusso1, Amander T Clark1

  • 1Department of Molecular, Cell and Developmental Biology, University of California, 90095 Los Angeles, CA, USA; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, 90095 Los Angeles, CA, USA.; Molecular Biology Institute, University of California, 90095 Los Angeles, CA, USA; Center for Reproductive Science, Health and Education, University of California, 90095 Los Angeles, CA, USA.

Current opinion in genetics & development
|July 13, 2023
PubMed
概括
此摘要是机器生成的。

可转移元素 (TE) 是基因组进化和基因调节的关键驱动因素,特别是在早期发育阶段. 新的干细胞模型提供了对它们在人类胚胎发育中的作用的见解.

更多相关视频

Protocol for Human Blastoids Modeling Blastocyst Development and Implantation
12:09

Protocol for Human Blastoids Modeling Blastocyst Development and Implantation

Published on: August 10, 2022

6.5K
Loss-of-Function Approach in the Embryonic Chick Retina by Using Tol2 Transposon-Mediated Transgenic Expression of Artificial microRNAs
06:58

Loss-of-Function Approach in the Embryonic Chick Retina by Using Tol2 Transposon-Mediated Transgenic Expression of Artificial microRNAs

Published on: May 18, 2022

1.1K

相关实验视频

Last Updated: Jul 23, 2025

Loss- and Gain-of-function Approach to Investigate Early Cell Fate Determinants in Preimplantation Mouse Embryos
08:43

Loss- and Gain-of-function Approach to Investigate Early Cell Fate Determinants in Preimplantation Mouse Embryos

Published on: June 6, 2016

8.9K
Protocol for Human Blastoids Modeling Blastocyst Development and Implantation
12:09

Protocol for Human Blastoids Modeling Blastocyst Development and Implantation

Published on: August 10, 2022

6.5K
Loss-of-Function Approach in the Embryonic Chick Retina by Using Tol2 Transposon-Mediated Transgenic Expression of Artificial microRNAs
06:58

Loss-of-Function Approach in the Embryonic Chick Retina by Using Tol2 Transposon-Mediated Transgenic Expression of Artificial microRNAs

Published on: May 18, 2022

1.1K

科学领域:

  • 基因组学就是基因组学.
  • 发展生物学 发展生物学
  • 分子进化分子进化

背景情况:

  • 转移性元素 (TE),曾经被认为是"垃圾DNA",现在被认为在塑造基因组中的重要作用.
  • 转基因对基因组进化,基因组组织和基因调节至关重要.
  • 它们的影响在胚胎发育早期特别明显.

研究的目的:

  • 总结当前对人类早期发展中的可转移元素的理解.
  • 探索基于新型干细胞的胚胎模型对研究TE的有用性.
  • 突出TE研究的计算和测序方法的进步.

主要方法:

  • 关于TE和早期发展的最新科学文献的综述.
  • 对干细胞技术进步的分析.
  • 整合下一代测序和计算方法.

主要成果:

  • 试验实验越来越被理解为对基因组创新和监管的积极贡献者.
  • 干细胞技术为模拟早期发育和TE活动提供了强大的工具.
  • 计算和测序方面的进步使得TE动态的详细分析成为可能.

结论:

  • 可转移的元素在早期哺乳动物和人类发育中发挥着基本作用.
  • 基于干细胞的胚胎模型对于未来对TEs的研究至关重要.
  • 使用这些模型进行进一步的研究将加深我们对 TE 对发展和进化的贡献的理解.