相关实验视频
Updated: Jul 23, 2025

10:30
Visualization of IL-22-expressing Lymphocytes Using Reporter Mice
Published on: January 25, 2017
8.9K
作为治疗干预的目标IL-22:关于其在各种疾病中的作用的当前知识
1Amity Institute of Virology & Immunology, Amity University Uttar Pradesh, Sector 125, Noida, India.
Cytokine
|July 13, 2023
概括
介质素22 (IL-22) 对于病原体防御和组织修复至关重要. 它的失调有助于疾病,使IL-22成为各种疾病的潜在治疗点.
科学领域:
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
- 细胞生物学 细胞生物学
背景情况:
- 介质素22 (IL-22) 是一个关键的细胞因子,参与宿主防御和组织再生.
- 失调的IL-22产生与许多疾病有关,包括癌症,病毒感染和自身免疫性疾病.
- IL-22属于IFN-IL-10细胞因子家族,主要由Th22细胞分泌,也由其他免疫细胞分泌.
研究的目的:
- 审查IL-22.2的基本生物学.
- 为了比较IL-22与干扰素- (IFN-γ).
- 探索IL-22作为各种疾病的免疫治疗点的潜力.
主要方法:
- 关于IL-22功能和相关细胞因子的文献评论.
- 分析Th22细胞特征及其在免疫中的作用.
- 讨论IL-22在疾病发病过程中的参与.
主要成果:
- Th22细胞仅生产IL-22并表达特定的转录因子和受体 (AHR,CCR6,CCR4,CCR10).
- 根据疾病背景和组织部位,IL-22具有双重作用 (保护性/致病性).
- IL-22功能由IL-22结合蛋白调节,该蛋白抑制受体结合.
结论:
- IL-22是表皮屏障免疫和抗微生物分泌的关键调解者.
- 了解IL-22的复杂作用对于开发向免疫疗法至关重要.
- IL-22代表了一系列炎症和自身免疫性疾病的有前途的治疗标.
相关概念视频
T Cell Types and Functions
1.1K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.1K
Tumor Immunotherapy
567
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
567
Targeted Cancer Therapies
7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.7K

