药物使用的严重程度可以通过药物类别来衡量吗? 估计不同药物类别在两种物质使用严重程度的一般措施中的差异性功能项目
Patrick Janulis1, Jing Luo2, Xiaodan Tang2
1Northwestern University, Department of Medical Social Sciences, United States; Northwestern University, Institute for Sexual and Gender Minority Health and Wellbeing, United States.
Drug and alcohol dependence
|July 13, 2023
概括
在不同类型的药物中,通用药物使用严重性的测量是可靠的. 研究结果表明,这些工具为药物特定评估提供了切实可行的替代方案,尽管建议进行进一步的研究.
科学领域:
- 心理测量 心理测量 心理测量
- 药物使用障碍 药物使用障碍
- 健康结果 测量 测量
背景情况:
- 一般项目通常用于测量物质使用严重程度.
- 评估不同物质的测量不变性对于得分可比性至关重要.
- 这项研究解决了对不同物质使用人口的通用措施的验证需求.
研究的目的:
- 检查不同物质使用严重性指标中的差异性项目功能 (DIF).
- 评估DIF对因子得分和组平均差异的影响.
- 确定通用措施是否适合在具有不同物质使用概况的个人中使用.
主要方法:
- 使用了两个独立的样本 (N=474,N=5183) 和两个通用指标:PROMIS物质使用严重性和DAST-10.
- 使用温和非线性因子分析估计DIF跨镇静剂,阿片类药物,胺类药物,可卡因和大麻.
- 通过使用有DIF调整和没有DIF调整的方法得出的比较因子得分.
主要成果:
- 一小部分项目展示了统计学上显著的DIF.
- 分数得分显示得分方法之间的相关性非常高 (0.994-0.999).
- 估计的物质组之间的平均差异在很大程度上是一致的,无论DIF调整.
结论:
- 药物使用的 PROMIS 严重性和 DAST-10 证明了不同物质的可接受测量不变性.
- 一般措施似乎是药物特定工具的节和有效的替代方案.
- 调查结果支持使用这些通用措施来评估不同人群中的物质使用严重程度,并呼吁继续验证.
相关概念视频
Substance Use Disorders Affecting Sleep
198
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
Understanding the concepts of physical dependence,...
198
Drug Classes and Categories
2.1K
Drugs can be classified according to their chemical composition or their intended therapeutic application. For instance, anti-infective agents that possess the ability to eliminate pathogens or suppress their growth and reproduction can be grouped based on the organisms they target or their chemical structure. Furthermore, drugs can be divided into prescription, nonprescription, or controlled substances. Prescription medications, such as antibiotics, require oversight from a licensed healthcare...
2.1K
Drug Abuse and Addiction: Pharmacological Phenomena
544
Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not...
544
Drug Dependence
1.1K
Medications are typically administered to achieve therapeutic effects. Some drugs can modify an individual's mood and perception, frequently resulting in various enjoyable experiences. However, this can result in drug dependency, a condition marked by continuous drug use despite potential negative consequences. Drug dependency primarily falls into two categories: psychological and physical dependence. Psychological dependence occurs when the pleasurable feelings induced by the drug...
1.1K
Drug Concentrations: Measurements
406
Drug concentration is the quantity of a drug present in a biological sample. Measuring drug amounts in biological samples allows the clinician to understand how a drug is absorbed, distributed, metabolized, and excreted. Samples can be obtained through invasive or non-invasive methods. Invasive techniques involve surgical or parenteral interventions to gather blood, cerebrospinal fluid, or tissue biopsy. Conversely, non-invasive approaches provide samples like urine, feces, and saliva.
Plasma...
Plasma...
406
Dose-Response Relationship: Selectivity and Specificity
7.0K
Drugs exert their therapeutic effects by interacting with receptors, enzymes, or ion channels that are present throughout the human body. The strength and duration of the interaction between a drug and its target receptor are characterized by the selectivity and specificity of the drug. Selectivity refers to a drug's strong preference for its intended target over other targets. For instance, isoprenaline, a non-selective β-adrenergic agonist, interacts with both β1- and...
7.0K


