炎症标志物和COVID-19疾病进展
Santosh Kumar Sidhwani1, Talat Mirza2, Ambrina Khatoon3
1Department of Pathology, Ziauddin University, Pakistan.
Journal of infection and public health
|July 13, 2023
概括
像CRP和LDH这样的炎症标志物的升高与COVID-19的严重程度有显著的关联. 了解这些标志物有助于预测和管理严重的冠状病毒病例.
科学领域:
- * 传染病 传染病
- * 临床医学 临床医学
- * 生物化学 * 生物化学
背景情况:
- *COVID-19大流行带来了全球卫生危机,正在研究疾病特征和传播.
- *在COVID-19患者中经常观察到升高的炎症标志物,因此需要进一步调查它们与疾病严重程度的关系.
- *了解这些标志物对于管理大流行和患者的结果至关重要.
研究的目的:
- * 调查特定的炎症标志物与COVID-19的严重程度之间的相关性.
- * 确定可以预测或表明COVID-19患者严重疾病进展的关键生物标志物.
主要方法:
- *进行了一项涉及143名COVID-19 PCR阳性患者的横截面研究.
- *关于人口统计,临床状况和实验室结果的数据从电子病历中收集.
- *研究期为2020年4月至9月,在齐亚丁医院进行.
主要成果:
- *大多数患者是老年男性,患有糖尿病和高血压等常见并发症.
- *几乎所有患者都观察到各种炎症标志物水平的增加,其中最常见的是前素 (97.2%).
- * 总白细胞计数 (TLC),C-反应蛋白 (CRP),乳酸脱酶 (LDH),费里丁,D-二次体和公素水平与COVID-19严重程度相关的显著差异被发现 (p <0.05对所有).
结论:
- * 炎症标志物水平升高与COVID-19严重程度之间存在显著的关联.
- *大多数炎症标志物,不包括前素,与疾病严重程度有显著的相关性.
- *这些发现有助于了解COVID-19的发病因子,并可能有助于预测和管理严重病例.
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