精神伴随性疾病和执行功能障碍之间的关联在缺血素-1的小儿麻醉症类型1中
Berit Hjelde Hansen1, Hilde Norsted Andresen2, Jonas Gjesvik3
1Norwegian Centre of Expertise for Neurodevelopmental Disorders and Hypersomnias, Department of Rare Disorders, Division of Paediatric and Adolescent Medicine, Oslo University Hospital, Norway.
小儿麻醉症1型 (PNT1) 患者经常出现精神障碍和执行功能障碍. 这些问题与低白-1缺乏有关,影响生活质量,需要综合性临床护理.
科学领域:
- 神经学 神经学
- 精神病学是一个精神病学.
- 睡眠医学 睡眠医学
背景情况:
- 麻醉症1型 (NT1) 严重影响学业成绩和生活质量,由于精神症状和认知缺陷.
- 儿科NT1 (PNT1) 提出了独特的挑战,需要了解相关精神疾病和执行功能障碍的患病率.
研究的目的:
- 评估PNT1患者中精神疾病和执行功能障碍的患病率.
- 探索PNT1.1中精神病并发症,执行功能障碍,睡眠测量和脑脊液 (CSF) 缺血蛋白-1水平之间的关联.
主要方法:
- 一项横截面研究包括59名PNT1患者 (6-20岁).
- 评估包括核心麻醉症症状,多重睡眠测试,多重睡眠延迟测试,中枢神经液中低白蛋白-1水平,精神疾病 (KSADS) 和执行功能障碍 (BRIEF).
主要成果:
- 超过一半的PNT1患者 (52.5%) 患有精神病并发症,64.7%表现出执行功能障碍.
- 精神病并发症和执行功能障碍相互关联,并与CSF低素-1缺乏症的严重程度有关.
- 较差的执行功能与增加的主观嗜睡相关.
结论:
- 在PNT1中观察到高水平的精神病并发症和执行功能障碍.
- 这些并发症显著与低素-1 缺乏症的严重程度有关.
- 对精神病和执行功能问题的综合临床关注对于PNT1患者护理至关重要.
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