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在为乳腺癌进行术后放射治疗后,加速后续的肺癌

Clémence Basse¹, Julien Ancel², Marie-Ange Massiani³

¹Thoracic Oncology, Institut Curie, Paris-St Cloud, France; University of Versailles Saint Quentin, Faculté de médecine Simone-Veil, Paris Saclay University, Versailles, France.

Lung cancer (Amsterdam, Netherlands)

|July 13, 2023

概括

乳腺癌 (BC) 的放射疗法可以加速随后的肺癌 (LC) 的发展. 临床医生应确定BC辐射治疗后的风险患者进行个性化监测.

科学领域:

在瘤学瘤学.
辐射瘤学辐射瘤学
癌症研究癌症研究

背景情况:

乳腺癌 (BC) 的术后放射治疗与随后的肺癌 (LC) 的风险增加有关.
辐射疗法强化 (称为提升) 对随后的LC风险的具体影响尚未被彻底研究.
了解辐射模式的作用对于管理BC幸存者的二次癌症风险至关重要.

研究的目的:

调查辐射方式的影响,特别是促进,在为局部乳腺癌 (BC) 治疗的患者中对随后的肺癌 (LC) 的发生率的影响.
确定与初级乳腺癌治疗后二级肺癌诊断时间相关的因素.
为乳腺癌幸存者的临床实践提供有关风险分层和监测策略的信息.

主要方法:

在2000年至2020年期间被诊断患有LC的患者的回顾性评估,这些患者有局部BC病史,经过手术和术后放射治疗.
主要终点:从BC放射治疗到首次诊断LC的时间.
统计分析以确定与LC诊断时间缩短相关的独立因素.

主要成果:

在98名患有随后LC的患者中,38%的患者接受了RT助推,46%的患者接受了激素治疗.
接受增剂 (4年) 患者的中位时间到LC诊断的时间明显较短,相比于未接受增剂 (8年) 患者 (p=0.007).
增强放射治疗,吸烟,内分泌疗法和BC辐射时年龄<50岁是与随后的LC更快发病相关的独立因素.

结论:

这项研究是第一个报告BC治疗中放射治疗增强与随后LC发展风险增加之间的潜在关联的研究.
低剂量辐射对肺瘤的影响可能有助于这种现象,尽管确切的生理病理学需要进一步调查.
临床医生必须确定患有第二次胸部恶性瘤的风险较高的患者,在BC辐射后实施量身定制的监测协议.

关键词:

乳腺癌乳腺癌乳腺癌低剂量辐射的辐射剂量很低.肺癌是一种肺癌.辐射疗法辐射疗法随后的后续的后续的

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