在现场固定共价有机框架作为静止阶段用于毛细血管电染色学
Yuanyuan Fu1, Zhentao Li1, Changjun Hu1
1Department of Orthopedics Trauma and Microsurgery, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430072, China; Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals, Wuhan 430071, China.
Journal of chromatography. A
|July 13, 2023
概括
开发了一种新的共价有机框架 (COF),作为开放管状电色谱的静止阶段. 这种COF材料证明了各种小型有机分子和药物的优异分离效率.
科学领域:
- 分析化学 分析化学
- 材料科学 材料科学 材料科学
背景情况:
- 聚合有机框架 (COF) 是具有可调节结构的晶体多孔聚合物.
- 开放管状电色谱 (OT-CEC) 是一种强大的分离技术,需要高效的静止相.
研究的目的:
- 合成和表征一种新的COF材料,用于OT-CEC中作为静止相.
- 评估COF修改列对各种分析物的分离性能.
主要方法:
- 在现场合成COF TZ-BPTA使用4,4',4′′-(1,3,5-Triazine-2,4,6-triyl) trianiline (TZ) 和2,5-bis(2-propyn-1-yloxy)-1,4-benzenedicarboxaldehyde (BPTA) 的方法.
- 在室温下将COF TZ-BPTA固定在毛细血管柱的内部表面.
- 使用SEM,FT-IR,XPS和XRD进行COF和修改列的表征.
- 分离抗药物,基,硫胺,PAHs,帕拉本,氨基酸和除草剂.
主要成果:
- 球形COF TZ-BPTA颗粒均地覆盖在毛细血管上.
- COF TZ-BPTA涂层柱实现了高分离分辨率和效率,最大效率超过2.8 × 10^5板·m-1.1.
- 观察到极好的可重复性,日内,日间和列对列运行精度低于1.70%RSD.
- 稳定的分离性能在100次运行中保持不变,该列成功分析了真实样本.
结论:
- 对于OT-CEC应用,COF TZ-BPTA是一个有前途的静止阶段.
- 现场合成和固定方法提供了一种有效的方法来准备高性能染色体列.
- 开发的基于COF的列显示了广泛适用于分离各种小型有机分子的应用.
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