在多发性硬化症中,sarcopenia和残疾之间的关系
Lukas Haider1, Karen K Chung2, Stephanie Mangesius3
1NMR Research Unit, Queen Square Multiple Sclerosis Centre, University College London Institute of Neurology, United Kingdom; Department of Biomedical Imaging and Image Guided Therapy, Medical University of Vienna, Austria.
Multiple sclerosis and related disorders
|July 13, 2023
概括
在患有多发性硬化症 (MS) 的个体中,临时肌肉厚度 (TMT) 变薄得更快,并且与疾病晚期的残疾相关. 然而,TMT稀释并不能预测MS患者未来的残疾进展.
科学领域:
- 神经学 神经学
- 肌肉生理学 肌肉生理学
- 关于残疾人的研究.
背景情况:
- 在多发性硬化症 (MS) 中,sarcopenia和残疾之间的关系尚不清楚.
- 研究肌肉变化可能为MS进展和患者的结果提供见解.
研究的目的:
- 检查患有MS的临床隔离综合征 (CIS) 个体的肌厚度 (TMT) 和残疾之间的关联.
- 为了确定随着时间的推移,TMT的变化是否与残疾进展相关.
主要方法:
- 一项前性队列研究追踪了132名患有CIS暗示MS的个人30年.
- 时间肌肉厚度 (TMT) 和扩展残疾状态量表 (EDSS) 在多个时间点进行了评估.
- 使用线性混合效应模型来分析TMT变化及其与残疾的相关性.
主要成果:
- 在患有多发性硬化症的人群中观察到加速的TMT稀释.
- 更薄的TMT与20岁和30岁更高的残疾分数 (EDSS) 有显著的关联.
- 早期的TMT测量没有预测长期临床结果或残疾进展.
结论:
- 时间肌肉厚度 (TMT) 稀薄在MS中加速,并且与晚期疾病阶段的残疾增加有关.
- 虽然TMT变化反映了疾病的进展,但它们不能预测未来的残疾.
- 对MS肌肉健康的进一步研究是有必要的.
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