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过敏反应和用化疗药物快速降低药物敏感性:一个三级参考中心的经验
İsmet Bulut1, Zeynep Yegin Katran1
1Department of Allergy and Immunology, Süreyyapasa Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.
International archives of allergy and immunology
|July 13, 2023
概括
快速降低药物敏感性使98%的患者能够接受全部化疗剂量,即使过敏. 这种有效的治疗方法使得癌症患者能够继续使用关键的第一线化疗剂.
科学领域:
- 在瘤学瘤学.
- 过敏和免疫学 过敏和免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 化疗剂可以引起过敏反应.
- 快速降低药物敏感性是管理这些反应的可行选择.
- 三级参考中心在诊断和治疗药物过敏症方面发挥着重要作用.
研究的目的:
- 检查经历过敏化疗剂的患者的特征.
- 评估化学疗法诱导过敏的诊断过程.
- 评估快速药物脱敏治疗对过敏的治疗结果.
主要方法:
- 在2016年1月至2022年9月期间,对51名患有化疗引起的过敏症患者进行了回顾性分析.
- 评估人口统计数据,癌症类型,化疗方案和皮肤测试结果.
- 根据反应严重程度和皮肤测试结果,采用16步或12步脱敏方案,并进行前期治疗,包括蒙特卢卡斯特, cetirizine 和 methylprednisolone.
主要成果:
- 奥克萨利普拉丁 (33.3%) 和帕克利塔塞尔 (25.4%) 是最常见的致病剂.
- 过敏反应或多系统参与发生在47%的患者中.
- 皮肤测试在56.6%的过敏患者中呈阳性.
- 98% (50/51) 的患者通过无敏化成功接受了他们的目标化疗剂量.
结论:
- 快速降低药物敏感性是非常有效的,成功率为98%,使患者能够完成化疗周期.
- 脱敏化允许继续使用必不可少的第一线化疗剂.
- 这种方法对于管理癌症患者的过敏反应至关重要,确保治疗的连续性.
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