通过下丘脑反应网络,在寻找食物和自我保护行为之间进行切换
Isabel de Araujo Salgado1, Chia Li1, C Joseph Burnett1
1Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Neuron
|July 13, 2023
概括
捕食者威胁迅速改变小鼠的行为,减少寻找食物. 涉及胆囊托基宁 (Cck) 和阿古蒂相关 (AgRP) 神经元的神经通路调解这些生存驱动的养策略转变.
科学领域:
- 神经科学是一个神经科学.
- 行为生物学 行为生物学
- 生理学 生理学 生理学
背景情况:
- 动机行为通常被孤立地研究,但在自然界,多个神经系统相互作用.
- 了解动物如何做出生存决策,比如平衡寻找食物与掠食威胁,至关重要.
研究的目的:
- 研究小鼠的灵活生存决策,平衡寻找食物和掠食威胁.
- 阐明潜在的神经机制威胁唤起的低食症和适应性养策略.
主要方法:
- 将小鼠暴露在掠食者威胁和环境干扰的环境中.
- 监测生理,神经和行为适应.
- 在背前乳腺核 (PMd) 和饥饿敏感的阿古蒂相关 (AgRP) 神经元中对危险反应的胆囊托基宁 (Cck) 细胞的选择性操纵.
主要成果:
- 捕食者暴露引起了快速的生理,神经和行为变化,减少了根据威胁水平寻找食物和消费.
- 在PMd中操纵Cck细胞抑制了AgRP神经元,揭示了威胁诱导的低机制.
- 增加的热量需求促进了通过AgRP通道到末端 (BNST) 和横向下丘脑 (LH) 的床核的威胁下寻找食物.
结论:
- 自我保护和寻找食物系统之间的神经相互作用使得自适应性行为灵活性成为可能.
- 这项研究确定了特定的神经回路 (Cck/PMd和AgRP/BNST/LH),它们调解了在受到威胁的情况下食和生存之间的权衡.
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