在接受腹腔大动脉瘤修复的成年人中,结果的性别差异
Niveditta Ramkumar1, Bjoern D Suckow2, Jesse A Columbo3
1Geisel School of Medicine, Hanover, NH.
Journal of vascular surgery
|July 13, 2023
概括
在腹腔大动脉瘤 (AAA) 修复后的长期结果显示,男性和女性的重新干预和破裂率相似. 需要进一步的研究来探索修复类型和临床表现如何影响这些性别差异.
科学领域:
- 血管外科 血管外科
- 健康 结果 研究 研究 结果
- 医学中的性别差异.
背景情况:
- 在腹腔大动脉瘤 (AAA) 修复后的短期结果显示已知的性别差异.
- 在AAA修复后,与性相关的长期不良结果,包括重新干预和晚期破裂,理解程度较低.
研究的目的:
- 调查腹腔大动脉瘤 (AAA) 修复后短期结果的性别差异是否会持续到长期的不良事件.
- 为了比较AAA修复后的男性和女性患者之间的重新干预和晚期动脉瘤破裂率.
主要方法:
- 对13007名接受内血管 (EVAR) 或开放 (OAR) AAA修复的患者进行了回顾性队列研究 (2003-2015).
- 利用与医疗保险索赔相关的血管质量倡议注册表来识别迟到的结果.
- 分析了破裂的10年发病率和动脉瘤特异性重新干预,调整了风险因素.
主要成果:
- 在风险调整 (HR=1.13) 后,女性 (人年4.8/1000) 和男性 (人年3.9/1000) 之间10年破裂发生率没有统计学上显著的差异.
- 在风险调整后 (HR=0.95) 女性 (5.1/1000人/年) 和男性 (4.8/1000人/年) 之间观察到类似的再干预率.
- 根据修复类型和临床表现的效果修改表明,在重新干预风险中存在潜在的性别特异性差异,尽管在子组中没有统计学意义.
结论:
- 男性和女性患者在AAA修复后10年内表现出可比的重新干预和晚期动脉瘤破裂率.
- 修复类型和临床表现可能会调节性对AAA修复后的长期结果的影响,需要进一步调查.
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