肝硬度测量的动态预测了晚期慢性肝病的结果
Georg Semmler1, Zhenwei Yang2, Laurenz Fritz3
1Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria; Vienna Hepatic Hemodynamic Laboratory, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
Gastroenterology
|July 13, 2023
概括
重复的肝硬度测量 (LSMs) 可以预测晚期慢性肝病 (ACLD) 患者的肝病进展和死亡率. 小规模企业的变化提供了比单个测量或其他评分系统更准确的风险评估.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 非侵入性诊断是一种非侵入性诊断.
- 预测模型的预测建模.
背景情况:
- 肝硬度测量 (LSMs) 对于监测肝病至关重要.
- 评估LSM动态的预后价值对于患者管理至关重要.
研究的目的:
- 评估慢性肝病患者的肝脏相关事件和死亡的LSM动态随时间的预后相关性.
主要方法:
- 追溯队列研究包括2508名患有慢性肝病的患者.
- 根据基线LSM分层为非ACLD,补偿ACLD (cACLD) 和减补ACLD.
- 对连续LSM和临床结果的分析,平均随访时间为71个月.
主要成果:
- 在cACLD患者中,LSM增加20%与肝脏衰竭和肝脏相关死亡风险增加50%有关.
- LSM动态准确预测了肝脏衰减补偿 (AUC=0.933),表现优于其他得分.
- 在cACLD患者中,LSM降低至<20kPa显著降低了脱补偿风险.
结论:
- 重复的LSM评估提供了个性化,更新的风险分层,用于ACLD的脱补偿和死亡率.
- 与单个时间点测量和其他评分系统相比,LSM动态提供了更好的预后信息.
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