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周围损伤对神经免疫信号传递的发育影响

Adam J Dourson1, Michael P Jankowski2

  • 1Department of Anesthesia, Division of Pain Management, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States; Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO, United States.

Brain, behavior, and immunity
|July 13, 2023
PubMed
概括

外周损伤会触发神经免疫反应,影响持续的疼痛. 这篇评论探讨了神经免疫信号传递,细胞免疫记忆,以及神经和免疫系统的影响,将研究结果与人类患者联系起来.

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Neurogenesis and Regeneration of Nervous Tissue01:15

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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