甜味偏好与较大的下丘脑对葡萄糖的反应和纵向体重增加有关
Alexandra G Yunker1, Sandhya P Chakravartti2, Stephanie Kullmann3
1Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Physiology & behavior
|July 13, 2023
概括
增加甜味偏好与增加的下丘脑激活,以应对葡萄糖和更大的体重增加有关. 这表明,与甜食渴望相关的体重增加风险的潜在神经标志物.
科学领域:
- 神经科学是一个神经科学.
- 代谢健康 代谢健康
- 人体生理学 人体生理学
背景情况:
- 下丘脑通过甜味受体调节能量稳定和葡萄糖感应.
- 喜欢甜食与体重增加有关,但与下丘脑食欲调节的联系尚不清楚.
研究的目的:
- 调查甜味偏好是否与葡萄糖的下丘脑激活相关.
- 为了确定甜味偏好是否预测身体质量指数 (BMI) 的纵向增加.
主要方法:
- 54名成人 (18-35岁) 与不同的BMI参与了这项研究.
- 使用强制选择跟踪程序测量了甜味偏好.
- 使用动脉旋转标记MRI评估下丘脑血流对葡萄糖的反应.
主要成果:
- 甜味偏好与与葡萄糖相关的下丘脑血流 (p=0.043) 有积极的关联.
- 在甜味偏好和纵向BMI变化 (p=0.015) 之间发现了积极的关联.
结论:
- 较高的甜味偏好与较大的葡萄糖诱导的下丘脑激活有关.
- 增加甜味偏好可能表明对体重增加的敏感性更高.
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