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Alexandra E Butler¹, Edwina Brennan¹, Daniel S Drage²

¹School of Medicine, Royal College of Surgeons in Ireland-Medical University of Bahrain, Busaiteen, Bahrain.

|July 13, 2023

概括

聚乙烯乙烯 (PBDE) 与女性的维生素D3 (25(OH) D3水平没有相关性. 然而,PBDE与活性维生素D代谢物 (1,25(OH) 2D3) 的相关性不同,这表明可能对维生素D状况产生影响.

科学领域:

环境健康环境健康
内分泌学在内分泌学.
营养科学营养科学

背景情况:

聚甲基乙 (PBDE) 是一种阻燃剂,已知会破坏内分泌功能.
PBDE可能会诱导影响维生素D3代谢的肝酶.
这项研究调查了PBDE暴露与女性维生素D水平之间的联系.

研究的目的:

为了检查PBDE和维生素D3 (25(OH) D3) 水平之间的关联.
调查PBDE与活性维生素D代谢物 (1,25(OH) 2D3) 之间的关联.
探索与BMI,功能和CaMK1.1的潜在相关性.

主要方法:

在58名非肥胖女性中测量了7个PBDE和总PBDE.
使用质谱学量化了25 (((OH) D3和1,25 (((OH) 2D3.
通过蛋白质组学评估血CaMK1水平.

主要成果:

在PBDE和25(OH) D3或1,25(OH) 2D3.3之间没有总体相关性.
在足够的维生素D子集中,1,25(OH) 2D3与PBDE153和PBDE100负相关.
在缺乏维生素D的子集中,1,25(OH) 2D3与PBDE153和总PBDE正相关.

结论:

PBDE与整体25(OH) D3水平没有关联.
特定的PBDEE (PBDE100,PBDE153) 与活性维生素D代谢物1,25(OH) 2D3.3相关.
PBDE153也与CaMK1相关,这表明PBDE对维生素D代谢的影响的潜在机制.

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