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使用定量蛋白质组学解读与婴儿性别相关的母乳中素分量的差异
Ce Wang1, Shilong Jiang2, Jianjun Cheng3
1National Engineering Research Center of Seafood, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, China; Department of Food Science, College of Food Science and Engineering, Jilin University, Changchun 130062, China.
International journal of biological macromolecules
|July 13, 2023
概括
人类牛奶的蛋白质成分因婴儿的性别而异. 这项研究确定了95种不同丰富的蛋白质在母乳中男性与女性婴儿,影响婴儿营养和免疫调节.
科学领域:
- 蛋白质组学是指蛋白质组学.
- 人母奶的成分 人母奶的成分
- 婴儿营养 婴儿营养
背景情况:
- 人母乳是婴儿的最佳营养.
- 婴儿的性别可能会影响母乳蛋白质的特征.
研究的目的:
- 为了识别和量化母乳中的素分片蛋白质.
- 为了研究母乳蛋白质成分的性别特异性差异.
主要方法:
- 没有4D标签的定量蛋白质组学.
- 分析母乳中的素分数,来自男婴和女婴的母亲.
主要成果:
- 鉴定了2064种蛋白质;其中95种具有差异丰富性.
- 对于男婴的牛奶中,21种蛋白质是上调的,59种是下调的.
- 免疫球蛋白V组域蛋白在差异丰富的蛋白质中最为丰富.
结论:
- 在母乳乳酪蛋白成分中存在显著的基于性别的差异.
- 这些发现可能有助于理解婴儿营养和免疫发育.
- 蛋白质变异突出了母乳养的潜在性别特异性益处.
相关概念视频
Peptide Identification Using Tandem Mass Spectrometry
Tandem mass spectrometry, also known as MS/MS or MS2, is an analytical technique that employs two mass analyzers. Essentially it is a series of mass spectrometers that helps isolate a particular biomolecule and then helps study its chemical properties.
This technique helps gather information regarding the protein from which the peptide was obtained and to study the peptides’ amino acid sequence. Identifying peptides from a complex mixture is an important component of the growing field of...
This technique helps gather information regarding the protein from which the peptide was obtained and to study the peptides’ amino acid sequence. Identifying peptides from a complex mixture is an important component of the growing field of...
Proteomics
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...

