可注射的多功能碳素甲基基托/氨酸水凝,用于药物输送系统
Fengjiao Zhang1, Sufeng Zhang1, Rui Lin1
1Shaanxi Provincial Key Laboratory of Papermaking Technology and Specialty Paper Development, Shaanxi University of Science and Technology, Xi'an 710021, China.
International journal of biological macromolecules
|July 13, 2023
概括
这项研究介绍了一种用于药物输送的新型注射水凝. 开发的四级氨碳素甲基基托和氨酸水凝具有出色的自我愈合,机械强度和持续的药物释放.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 药物输送系统 药物输送系统
背景情况:
- 可注射的水凝由于其机械性能和自我愈合能力,对药物输送有希望.
- 开发先进的水凝载体需要简单的合成方法和可调节的特性.
研究的目的:
- 为了合成和描述一种新的可注射,自我愈合,对pH值有反应的水凝,用于药物输送应用.
- 为了评估水凝的机械性能,可注射性,药物负载,释放动力学和生物相容性.
主要方法:
- 通过希夫基和协调键合成水凝,使用四级氨碳甲基酸盐 (QCS) 和用酸二二化物 (ADH) 和离子 (Ca2+) 改性甲基酸 (OHA).
- 评价凝时间,机械强度 (压缩应力),自我愈合效率,pH响应和抗菌活性.
- 使用细胞增殖试验评估药物负载能力,持续释放药物概况和体外细胞毒性.
主要成果:
- 该QCS + OHA + ADH + Ca2+水凝证明了快速凝 (∼54秒),确保了可注射性.
- 实现了显著的机械性能 (压力应力高达896.30 KPa),高自愈能力 (高达94%) 和良好的pH响应.
- 呈现出优良的抗菌性质,高的药物载荷能力 (121.3 mg/g) 和持续的药物释放 (≥120 h),具有良好的细胞相容性 (高达98%的细胞增殖).
结论:
- 开发的可注射水凝具有出色的机械性能,自我愈合,pH响应和抗菌特性.
- 这种水凝作为药物输送系统的高效载体,显示持续释放和良好的生物相容性.
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