口腔微生物组与胰岛素抵抗之间的联系:MAP激酶信号通路的参与
Yi-Ru Chang1, Wen-Chi Cheng2, Ya-Chun Hsiao3
1Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsinchu, Taiwan; General Biologicals Corporation, Hsinchu, Taiwan.
Biochimie
|July 13, 2023
概括
牙周细菌如Fusobacterium nucleatum和Tannerella forsythia与糖尿病有关. 这些细菌通过ERK信号通路在肝细胞中促进胰岛素抵抗.
科学领域:
- 微生物学 微生物学
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
背景情况:
- 口腔失生症和牙周炎与全身性疾病有关.
- 糖尿病是一种影响葡萄糖调节的代谢障碍.
- AMP激活蛋白激酶 (AMPK) 对于葡萄糖平衡至关重要.
研究的目的:
- 调查特定牙周细菌与糖尿病之间的关联.
- 阐明口腔细菌诱导胰岛素耐药性的分子机制.
主要方法:
- 临床试验比较了糖尿病患者和健康人的口腔细菌水平.
- 对Fusobacterium nucleatum培养液 (FNCF) 对人类牙上皮细胞 (Smulow-Glickman细胞) 的影响的分析.
- 通过托尔类受体2 (TLR2) 信号传导,研究FNCF诱导的细胞因子释放及其对肝细胞胰岛素抵抗路径的影响,包括细胞外信号调节激酶 (ERK) 路径.
主要成果:
- 在糖尿病患者中发现了Fusobacterium nucleatum (Fn) 和Tannerella forsythia (Tf) 的升高水平.
- Fn和Tf水平与空腹血糖和HbA1C正相关.
- FNCF通过TLR2诱导细胞因子释放,通过ERK/IRS1/AKT通路导致肝细胞的胰岛素抵抗,影响GSK3β和GS.
结论:
- 富索细菌核酸菌和Tannerella forsythia与糖尿病有关.
- 牙周细菌通过TLR2和ERK信号通路促进胰岛素抵抗.
- 准ERK通路可能提供一种管理糖尿病相关胰岛素抵抗的策略.
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