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减肥手术可以帮助预防自身免疫?
Ana Paula Beckhauser1, Renato Nisihara2, Alessandro F Tonial1
1Medical Research Institute, Evangelical Mackenzie University, Curitiba, Paraná, Brazil.
Archives of medical research
|July 13, 2023
概括
肥胖与自身免疫性疾病有关. 肥胖患者的腹腔外科手术显著降低了抗核抗体 (ANA),表明体重减轻可能会影响自身免疫标志物.
科学领域:
- 免疫学 免疫学 免疫学
- 内分泌学 在内分泌学.
- 胃肠病学 胃肠病学
背景情况:
- 肥胖越来越被认为是导致自身免疫性疾病的发展和进展的一个因素.
- 了解与肥胖和减肥相关的免疫变化对于管理相关健康状况至关重要.
研究的目的:
- 调查在接受减肥手术的患者中特定自身抗体的流行率.
- 评估减肥手术和随后的体重减轻对自身抗体水平的影响.
主要方法:
- 来自79名减肥手术患者的血清在手术前和手术后被分析为抗核抗体 (ANA),类风湿因子 (RF),抗心脂蛋白抗体和抗内膜性抗体.
- 对ANA阳性血清进行了进一步测试,以检测抗dsDNA和ENA配置文件. 通过图表审查收集了临床和人类学数据.
主要成果:
- 在手术前的ANA阳性被观察到在29.1%的患者中,在术后显著下降到10.1% (p=0.002).
- 最常见的是细斑点的ANA图案. 阳性ANA患者在手术前维生素D水平较低 (p=0.002).
- 射频阳性显示了非显著的下降趋势. 手术后. 其他测试的抗体在很大程度上是负的.
结论:
- 抗核抗体在接受减肥手术的肥胖个体中很常见.
- 腹部外科手术诱导的体重减轻与ANA患病率的显著降低有关,这表明体重管理在调节自身免疫标志物的潜在作用.
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