顺序的静脉注射葛西他和多塞塔克塞尔用于以前未接受过治疗和先前接受过治疗的中等风险非肌肉侵入性膀癌
Ian M McElree1, Joanna Orzel2, Reid Stubbee2
1Carver College of Medicine, University of Iowa, Iowa City, IA.
Urologic oncology
|July 13, 2023
概括
辅助性静脉内凝丁-多克塞尔 (Gem/Doce) 治疗显示,中等风险非肌肉侵入性膀癌 (NMIBC) 的无复发生存率为71%. 以前没有接受过治疗的患者比以前接受过治疗的患者有更好的结果.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 辅助静脉治疗是中等风险非肌肉侵入性膀癌 (NMIBC) 的标准.
- 在高风险的NMIBC中确立了静脉内凝丁-多克塞尔 (Gem/Doce),但其在中等风险病例中的疗效定义较差.
研究的目的:
- 在中等风险NMIBC患者中评估辅助性静脉内凝丁-多克塞尔 (Gem/Doce) 治疗的结果.
- 评估该患者群体中Gem/Doce的无复发生存率 (RFS) 和耐受性.
主要方法:
- 在TURBT后 (2012-2022) 接受Gem/Doce治疗的77名中等风险NMIBC患者的回顾性分析.
- 患者接受了连续6周的静脉注射凝胺 (1g) 和多塞 (37.5mg),随后进行维持治疗.
- 使用Kaplan-Meier分析评估了无复发生存期 (RFS).
主要成果:
- 所有患者的2年RFS为71%.
- 与之前接受治疗的患者 (64%) (P=0.04) 相比,以前未接受治疗的患者显著改善了RFS (79%).
- 一般来说,Gem/Doce的耐受性很好,大多数不良事件是1-2级;3.9%的人停止了治疗.
结论:
- 辅助性静脉注射Gem/Doce在中等风险NMIBC中显示出有效性和良好的耐受性.
- 需要进一步的前性研究来证实在这个特定的患者群体中这些发现.
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