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阿迪波基因在肉症中的作用
Wenhao Lu1,2, Wenjie Feng3, Jieyu Lai4
1Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Chinese medical journal
|July 13, 2023
概括
衰老的肌肉损失,或肉,与增加的体脂和特定的脂肪分泌的荷尔蒙称为adipokines有关. 了解这些阿迪波金是制定与年龄相关的肌肉衰退干预措施的关键.
科学领域:
- 老年学是指老年学的学科.
- 内分泌学 在内分泌学.
- 肌肉生理学 肌肉生理学
背景情况:
- 萨科佩尼亚是一种与年龄相关的疾病,其特点是肌肉质量,强度和功能下降.
- 衰老与身体脂肪增加有关,特别是内脏脂肪,它充当内分泌器官.
- 脂肪组织分泌adipokines,生物活性因素影响局部和遥远的组织,包括肌肉.
研究的目的:
- 描述由脂肪组织产生的各种阿迪波金 (莱普丁,阿迪波涅克丁,抵抗素,粘素,利波卡林-2) 对肌肉的影响.
- 讨论这些阿迪波基因在理解萨尔科佩尼亚发展中的重要性.
主要方法:
- 对adipokine对肌肉的影响现有研究的综述.
- 分析特定阿迪波金的调节作用,如瘦素和阿迪波涅丁,在肌肉质量和功能.
主要成果:
- 血清瘦素水平升高与肌肉功能降低有关.
- 通过通过PGC-1α激活和胰岛素敏感化抑制与缩相关的基因 (atrogin-1,MuRF1) 来抑制肌肉缩,阿迪波涅丁可以抑制肌肉缩.
- 其他阿迪波金 (adipokine),如抵抗素 (resistin),粘素 (mucin) 和利波卡林-2 (lipocalin-2) 也会影响肌肉,但它们在肉症中的作用需要进一步阐明.
结论:
- 阿迪波基因在调节肌肉质量,力量和功能方面发挥着至关重要的作用.
- 了解脂肪组织和肌肉之间的复杂相互作用通过adipokines对于解决sarcopenia至关重要.
- 针对特定的阿迪波金可以为与年龄相关的肌肉损失提供治疗策略.
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