相关实验视频

Updated: Jul 23, 2025

Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus

Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus

Published on: December 7, 2013

一个与cuproptosis相关的新型诊断基因签名和在动脉样硬化中的差异表达验证

Yuting Cui¹, Yanyu Chen¹, Ni Gan²

¹Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, School of Basic Medical Sciences, Hengyang Medical School, University of South China, Hengyang, 421001, China.

Molecular biomedicine

|July 13, 2023

概括

这项研究揭示了与cuproptosis相关的基因在动脉样硬化 (AS) 中的关键作用. 关键基因FDX1,SLC31A1和GLS在AS斑块中表现出改变,为这种心血管疾病提供了潜在的诊断生物标志物.

科学领域:

心血管生物学心血管生物学
细胞死亡途径细胞死亡途径
分子医学是分子医学.

背景情况:

动脉样硬化 (AS) 是全球死亡的主要原因,其潜在的分子机制仍在研究中.
铜平衡与心血管疾病有关,并且出现了一种与铜过量相关的新型细胞死亡途径 - - 铜亡.
没有先前的研究探讨了 cuproptosis 和AS发展之间的联系.

研究的目的:

通过使用集成测序数据,识别参与动脉生成的关键cuproptosis相关基因.
研究这些基因在动脉样硬化斑块中的表达模式和诊断潜力.
为了阐明在动脉样硬化病变中发现的基因的细胞局部.

主要方法:

来自动动脉硬化样本的大量和单细胞测序数据的整合.
生物信息分析包括相关性,丰富和随机森林.
对基因表达和细胞局部化的实验验证.

主要成果:

发现FDX1和SLC31A1在动脉样硬化斑块中受到上调,而GLS在动脉样硬化斑块中受到下调.
接收器运行特征 (ROC) 曲线表明AS中这些基因的诊断潜力.
主要在血管光滑肌细胞中观察到GLS表达,在动脉样硬化病变内的巨细胞中观察到SLC31A1.

结论:

这项研究确定了与cuproptosis相关的基因 (FDX1,SLC31A1,GLS) 和动脉样硬化之间的一种新的联系.
这些基因代表了AS的潜在诊断生物标志物,有助于早期检测和理解.
这些发现突显了cuproptosis在动脉样硬化进展中的重要作用.

关键词:

动脉样硬化是一种动脉样硬化.动脉样硬化心血管疾病.生物信息学是一种生物信息学.这种疾病叫做cuproptosis.

更多相关视频

Quantification of Atherosclerosis in Mice

Quantification of Atherosclerosis in Mice

Published on: June 12, 2019

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology

Published on: May 6, 2014

相关概念视频

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...

Atherosclerosis I: Introduction

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...