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低HER2的乳腺癌: HER2表达的演变从原发性瘤到远程转移

Mengyuan Cai^1,2,3, Ming Li^1,2,3, Hong Lv^1,2,3

¹Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.

|July 13, 2023

概括

在乳腺癌转移中,HER2的表达会发生变化,其速率因转移部位,原发性瘤阶段和活检类型而异. 转移中的这些HER2表达变化没有影响患者的生存结果.

科学领域:

在瘤学瘤学.
病理学病理学病理学
医学诊断医学诊断医学诊断

背景情况:

由于新的抗HER2疗法,HER2-低乳腺癌 (BC) 正在引起人们的注意.
了解转移中的HER2表达动态对于治疗决策至关重要.

研究的目的:

调查 HER2 表达状态在初级 HER2 低乳腺癌及其远程转移.
分析影响转移中的HER2状态变化的因素及其预后影响.

主要方法:

对98名在2012-2021年期间被诊断为低HER2BC患者 (IHC1+或IHC2+/ISH-) 的回顾性分析.
在初级瘤和转移部位中评估HER2表达.
基于转移部位,初级瘤T阶段和转移样本类型的HER2异常率的比较.

主要成果:

在27.6%的患者中,HER2状态在转移方面有所不同.
不一致率因转移部位,初级T阶段和转移样本类型 (活检与外科手术) 不同.
根据转移中的HER2状态,没有观察到总体存活率或无病存活率的显著差异.

结论:

在HER2-低乳腺癌的转移中,HER2表达可能会发生改变.
HER2变化的速度受到转移部位,原发性瘤阶段和样本类型的影响.
在HER2-低BC转移中改变HER2表达似乎没有预后意义.

关键词:

抗HER2抗体与药物联合的抗HER2抗体.乳腺癌是什么? 乳腺癌是什么这就是HER2异调.HER2-低表达的表达方式.转移转移转移转移

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